Effects of Pro-Gly-Pro Tripeptide on the Dopamine System

Tripeptide Pro-Gly-Pro interacted with dopamine receptors in vitro and reduced behavioral manifestations of apomorphine-induced hyperfunction of the dopamine system in verticalization, stereotypy, and yawning tests. Presumably, the behavioral effects of Pro-Gly-Pro tripeptide were mediated through p...

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Published inBulletin of experimental biology and medicine Vol. 151; no. 4; pp. 429 - 431
Main Authors Meshavkin, V. K., Batishcheva, E. Yu, Kost, N. V., Sokolov, O. Yu, Trufanova, A. V., Samonina, G. E.
Format Journal Article
LanguageEnglish
Published Boston Springer US 01.08.2011
Springer
Springer Nature B.V
Subjects
Animals
Behavior, Animal - drug effects
Biomedical and Life Sciences
Biomedicine
Cell Biology
Dopamine receptors
Glycine
Internal Medicine
Laboratory Medicine
Male
Mice
Oligopeptides - pharmacology
Pathology
Peptides
Phenols
Proline - analogs & derivatives
Proline - pharmacology
Receptors, Dopamine D2 - drug effects
Receptors, Dopamine D2 - metabolism
Receptors, Dopamine D3 - drug effects
Receptors, Dopamine D3 - metabolism
Synapses - drug effects
Synapses - metabolism
glyprolines
dopamine receptors
apomorphine-induced verticalization
Pro-Gly-Pro
stereotypy
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Summary:Tripeptide Pro-Gly-Pro interacted with dopamine receptors in vitro and reduced behavioral manifestations of apomorphine-induced hyperfunction of the dopamine system in verticalization, stereotypy, and yawning tests. Presumably, the behavioral effects of Pro-Gly-Pro tripeptide were mediated through post- and presynaptic D 2 and D 3 receptors.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-011-1348-2