Immunohistochemical prognostic factors in resected colorectal lung metastases using tissue microarray analysis

• Published in: European journal of surgical oncology Vol. 32; no. 3; pp. 308 - 309
• Main Authors: Shiono, S., Ishii, G., Nagai, K., Murata, Y., Tsuta, K., Nitadori, J., Kodama, T., Ochiai, A.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.04.2006
• Subjects: beta Catenin - metabolism; Biomarkers, Tumor - metabolism; Cadherins - metabolism; Carcinoma - metabolism; Carcinoma - secondary; Carcinoma - surgery; Colorectal cancer; Colorectal Neoplasms - metabolism; Colorectal Neoplasms - pathology; E-cadherin; Humans; Immunohistochemistry; Lung; Lung Neoplasms - metabolism; Lung Neoplasms - secondary; Lung Neoplasms - surgery; Metastasis; Pneumonectomy; Prognosis; Receptor, IGF Type 1 - metabolism; Retrospective Studies; Tumor Suppressor Protein p53 - metabolism; Immunohistochemistry; Metastasis; E-cadherin; Lung; Colorectal cancer
• ISSN: 0748-7983; 1532-2157
• DOI: 10.1016/j.ejso.2005.12.003

Immunohistochemical prognostic factors of pulmonary metastatic colorectal cancer lesions have not been well investigated. The study was conducted to identify the immunohistochemical prognostic factors of metastasized colorectal cancer. We immunohistochemicaly investigated the expression of insulin-like growth factor-1 receptor (IGF1-R), E-cadherin, ß-catenin, and p53 using a tissue microarray in the surgical specimens of 86 metastatic lesions. The univariate analysis revealed E-cadherin and membrane ß-catenin positive to be prognostic factors. IGF1-R and p53 were not significantly associated with the patient's survival. In multivariate analysis, the reduced expression of E-cadherin, aerogenous spread with floating cancer cell clusters and vascular invasion were independent prognostic factors. The reduced expression of E-cadherin in the pulmonary metastatic lesions was an independent predictor of poor survival after pulmonary metastasectomy.