Myocardin in biology and disease
Myocardin （MYOCD） is a potent transcriptional coactivator that functions primarily in cardiac muscle and smooth muscle through direct contacts with serum response factor （SRF） over cis elements known as CArG boxes found near a number of genes encoding for contractile, ion channel, cytoskeletal, and...
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| Published in | Journal of biomedical research Vol. 29; no. 1; pp. 3 - 19 |
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| Main Author | |
| Format | Journal Article |
| Language | English |
| Published |
China
Editorial Department of Journal of Biomedical Research
01.01.2015
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| Abstract | Myocardin （MYOCD） is a potent transcriptional coactivator that functions primarily in cardiac muscle and smooth muscle through direct contacts with serum response factor （SRF） over cis elements known as CArG boxes found near a number of genes encoding for contractile, ion channel, cytoskeletal, and calcium handling proteins. Since its discovery more than 10 years ago, new insights have been obtained regarding the diverse isoforms of MYOCD expressed in cells as well as the regulation of MYOCD expression and activity through transcriptional, post-transcriptional, and post-translational processes. Curiously, there are a number of functions associated with MYOCD that appear to be independent of contractile gene expression and the CArG-SRF nucleoprotein complex. Further, perturbations in MYOCD gene expression are associated with an increasing number of diseases including heart failure, cancer, acute vessel disease, and diabetes. This review summarizes the various biological and patho- logical processes associated with MYOCD and offers perspectives to several challenges and future directions for further study of this formidable transcriptional coactivator. |
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| AbstractList | Myocardin (MYOCD) is a potent transcriptional coactivator that functions primarily in cardiac muscle and smooth muscle through direct contacts with serum response factor (SRF) over cis elements known as CArG boxes found near a number of genes encoding for contractile, ion channel, cytoskeletal, and calcium handling proteins. Since its discovery more than 10 years ago, new insights have been obtained regarding the diverse isoforms of MYOCD expressed in cells as well as the regulation of MYOCD expression and activity through transcriptional, post-transcriptional, and post-translational processes. Curiously, there are a number of functions associated with MYOCD that appear to be independent of contractile gene expression and the CArG-SRF nucleoprotein complex. Further, perturbations in MYOCD gene expression are associated with an increasing number of diseases including heart failure, cancer, acute vessel disease, and diabetes. This review summarizes the various biological and pathological processes associated with MYOCD and offers perspectives to several challenges and future directions for further study of this formidable transcriptional coactivator. Myocardin (MYOCD) is a potent transcriptional coactivator that functions primarily in cardiac muscle and smooth muscle through direct contacts with serum response factor (SRF) over cis elements known as CArG boxes found near a number of genes encoding for contractile, ion channel, cytoskeletal, and calcium handling proteins. Since its discovery more than 10 years ago, new insights have been obtained regarding the diverse isoforms of MYOCD expressed in cells as well as the regulation of MYOCD expression and activity through transcriptional, post-transcriptional, and post-translational processes. Curiously, there are a number of functions associated with MYOCD that appear to be independent of contractile gene expression and the CArG-SRF nucleoprotein complex. Further, perturbations in MYOCD gene expression are associated with an increasing number of diseases including heart failure, cancer, acute vessel disease, and diabetes. This review summarizes the various biological and pathological processes associated with MYOCD and offers perspectives to several challenges and future directions for further study of this formidable transcriptional coactivator. Myocardin （MYOCD） is a potent transcriptional coactivator that functions primarily in cardiac muscle and smooth muscle through direct contacts with serum response factor （SRF） over cis elements known as CArG boxes found near a number of genes encoding for contractile, ion channel, cytoskeletal, and calcium handling proteins. Since its discovery more than 10 years ago, new insights have been obtained regarding the diverse isoforms of MYOCD expressed in cells as well as the regulation of MYOCD expression and activity through transcriptional, post-transcriptional, and post-translational processes. Curiously, there are a number of functions associated with MYOCD that appear to be independent of contractile gene expression and the CArG-SRF nucleoprotein complex. Further, perturbations in MYOCD gene expression are associated with an increasing number of diseases including heart failure, cancer, acute vessel disease, and diabetes. This review summarizes the various biological and patho- logical processes associated with MYOCD and offers perspectives to several challenges and future directions for further study of this formidable transcriptional coactivator. |
| Author | Joseph M. Miano |
| AuthorAffiliation | Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA. |
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| Author_xml | – sequence: 1 givenname: Joseph M surname: Miano fullname: Miano, Joseph M organization: Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25745471$$D View this record in MEDLINE/PubMed |
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| Notes | 32-1810/R Myocardin （MYOCD） is a potent transcriptional coactivator that functions primarily in cardiac muscle and smooth muscle through direct contacts with serum response factor （SRF） over cis elements known as CArG boxes found near a number of genes encoding for contractile, ion channel, cytoskeletal, and calcium handling proteins. Since its discovery more than 10 years ago, new insights have been obtained regarding the diverse isoforms of MYOCD expressed in cells as well as the regulation of MYOCD expression and activity through transcriptional, post-transcriptional, and post-translational processes. Curiously, there are a number of functions associated with MYOCD that appear to be independent of contractile gene expression and the CArG-SRF nucleoprotein complex. Further, perturbations in MYOCD gene expression are associated with an increasing number of diseases including heart failure, cancer, acute vessel disease, and diabetes. This review summarizes the various biological and patho- logical processes associated with MYOCD and offers perspectives to several challenges and future directions for further study of this formidable transcriptional coactivator. ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 The author reported no conflict of interests. |
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| References | 19088079 - J Biol Chem. 2009 Feb 6;284(6):3728-38 25174608 - Genesis. 2014 Oct;52(10):879-87 25190111 - Int J Oncol. 2014 Nov;45(5):2024-32 15380248 - Curr Opin Genet Dev. 2004 Oct;14(5):558-66 23103763 - EMBO J. 2012 Nov 28;31(23):4428-40 1361191 - J Biol Chem. 1992 Dec 25;267(36):26085-90 24419809 - Eur Heart J. 2015 Jun 1;36(21):1335-45 19276386 - Cancer Res. 2009 Mar 15;69(6):2269-78 22996691 - J Clin Invest. 2012 Oct;122(10 ):3678-91 21357509 - Am J Physiol Heart Circ Physiol. 2011 May;300(5):H1707-21 10692439 - J Biol Chem. 2000 Mar 3;275(9):6381-7 20146266 - Stem Cells. 2010 Apr;28(4):734-42 22398275 - Atherosclerosis. 2012 May;222(1):84-91 3690668 - Cell. 1987 Dec 24;51(6):987-1000 21473868 - Gastroenterology. 2011 Jul;141(1):164-75 12392995 - J Mol Cell Cardiol. 2002 Oct;34(10):1345-56 21051663 - Arterioscler Thromb Vasc Biol. 2011 Feb;31(2):368-75 20691899 - Cell. 2010 Aug 6;142(3):375-86 15197188 - J Biol Chem. 2004 Aug 27;279(35):37124-32 12788374 - J Mol Cell Cardiol. 2003 Jun;35(6):577-93 20299686 - Arterioscler Thromb Vasc Biol. 2010 Jun;30(6):1203-11 17215356 - Proc Natl Acad Sci U S A. 2007 Jan 16;104(3):823-8 10969032 - Circ Res. 2000 Sep 1;87(5):355-62 17940050 - Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16570-5 16556869 - Circ Res. 2006 Apr 28;98(8):1089-97 24620720 - Andrologia. 2015 Apr;47(3):303-9 7754368 - Science. 1995 May 12;268(5212):836-44 12920479 - J Mol Med (Berl). 2003 Sep;81(9):566-77 19389706 - J Biol Chem. 2009 Jul 10;284(28):19027-42 19247948 - Int J Dev Biol. 2009;53(8-10):1457-67 19098903 - Nat Cell Biol. 2009 Feb;11(2):143-53 20566642 - J Biol Chem. 2010 Aug 27;285(35):27449-56 24769668 - FASEB J. 2014 Aug;28(8):3518-27 14645532 - Mol Cell Biol. 2003 Dec;23 (24):9222-32 17991879 - Circ Res. 2007 Dec 7;101(12):e115-23 24567363 - J Cell Biol. 2014 Mar 3;204(5):683-96 23946491 - J Biol Chem. 2013 Oct 4;288(40):28477-87 15657056 - J Biol Chem. 2005 Mar 18;280(11):10861-9 15550397 - J Biol Chem. 2005 Feb 11;280(6):4745-52 12215486 - Circ Res. 2002 Sep 6;91(5):382-9 8570656 - Proc Natl Acad Sci U S A. 1996 Jan 23;93(2):900-5 23643243 - Cell. 2013 May 9;153(4):910-8 15569937 - Proc Natl Acad Sci U S A. 2004 Dec 7;101(49):17132-7 24607789 - Cell Signal. 2014 Jun;26(6):1335-46 16054032 - Dev Cell. 2005 Aug;9(2):261-70 21792927 - J Cell Physiol. 2011 Oct;226(10):2702-11 11211058 - Neuropathology. 2000 Dec;20(4):319-25 15690088 - J Clin Invest. 2005 Feb;115(2):418-27 23825366 - Arterioscler Thromb Vasc Biol. 2013 Oct;33(10):2355-65 20847050 - J Biol Chem. 2010 Nov 26;285(48):37314-23 12756293 - Proc Natl Acad Sci U S A. 2003 Jun 10;100(12):7129-34 15919067 - Cardiovasc Res. 2005 Aug 15;67(3):438-47 24252873 - Elife. 2013 Nov 19;2:e01323 16224064 - Circ Res. 2005 Nov 11;97(10):983-91 16798818 - Am J Physiol Heart Circ Physiol. 2006 Nov;291(5):H2493-503 21817093 - Arterioscler Thromb Vasc Biol. 2011 Oct;31(10):2172-80 17021041 - Development. 2006 Nov;133(21):4245-56 18296632 - Proc Natl Acad Sci U S A. 2008 Mar 4;105(9):3362-7 20484220 - Cardiovasc Res. 2010 Sep 1;87(4):740-50 21157370 - J Hypertens. 2011 Apr;29(4):791-7 17360478 - Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):4065-70 23335105 - Stem Cells. 2013 May;31(5):906-17 16818234 - Mol Cell. 2006 Jul 7;23(1):83-96 5425010 - Exp Mol Pathol. 1970 Jun;12(3):354-62 19036941 - Am J Physiol Cell Physiol. 2009 Apr;296(4):C711-23 23963726 - Circ Res. 2013 Oct 12;113(9):1065-75 21183509 - Cardiovasc Res. 2011 Apr 1;90(1):28-37 19237536 - Mol Cell Biol. 2009 May;29(9):2398-408 21712382 - J Biol Chem. 2011 Aug 26;286(34):30119-29 21897873 - PLoS One. 2011;6(8):e24242 11439182 - Cell. 2001 Jun 29;105(7):851-62 22136926 - Cell Stem Cell. 2011 Dec 2;9(6):504-16 17495540 - Cell Cycle. 2007 May 15;6(10):1141-6 22580282 - Biochem Biophys Res Commun. 2012 Jun 1;422(2):285-90 19342595 - Arterioscler Thromb Vasc Biol. 2009 Jun;29(6):921-8 20177053 - J Biol Chem. 2010 Apr 16;285(16):11903-12 19578358 - Nature. 2009 Aug 6;460(7256):705-10 9218459 - J Biol Chem. 1997 Jul 18;272(29):18222-31 3203386 - Cell. 1988 Dec 23;55(6):989-1003 20385216 - Gene. 2010 Sep 15;464(1-2):1-10 15256479 - Circ Res. 2004 Aug 20;95(4):406-14 18039851 - Mol Cell Biol. 2008 Feb;28(3):1147-60 18451334 - Arterioscler Thromb Vasc Biol. 2008 Aug;28(8):1505-10 24144649 - Hypertension. 2014 Jan;63(1):119-27 15367672 - Mol Cell Biol. 2004 Oct;24(19):8519-28 16135793 - Mol Cell Biol. 2005 Sep;25(18):8009-23 23359472 - J Cell Physiol. 2013 Sep;228(9):1819-26 23007391 - J Biol Chem. 2012 Nov 9;287(46):38495-504 22017177 - Annu Rev Physiol. 2012;74:13-40 19574550 - Circ Res. 2009 Jul 31;105(3):214-8 22075245 - Arterioscler Thromb Vasc Biol. 2012 Jan;32(1):110-22 19793196 - Liver Int. 2010 Jan;30(1):42-54 22157009 - J Biol Chem. 2012 Jan 20;287(4):2459-67 12469122 - Nat Genet. 2003 Jan;33(1):49-54 20621093 - Exp Mol Pathol. 2010 Dec;89(3):301-6 3785189 - Mol Cell Biol. 1986 Jun;6(6):2125-36 12640126 - Mol Cell Biol. 2003 Apr;23(7):2425-37 18945672 - J Biol Chem. 2008 Dec 19;283(51):35383-92 20093628 - Circ Res. 2010 Mar 19;106(5):870-9 11133929 - J Appl Physiol (1985). 2001 Jan;90(1):358-68 24681789 - Hellenic J Cardiol. 2014 Mar-Apr;55(2):119-25 24133205 - J Biol Chem. 2013 Nov 29;288(48):34336-42 12867591 - Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9366-70 18069699 - Dev Dyn. 2008 Jan;237(1):216-21 24374035 - Arch Biochem Biophys. 2014 Feb 1;543:48-56 24248596 - Mol Cell Biol. 2014 Feb;34(3):400-14 22411986 - J Biol Chem. 2012 Apr 27;287(18):14598-605 21512281 - J Atheroscler Thromb. 2011;18(8):670-83 19850880 - Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18734-9 20388650 - Eur J Heart Fail. 2010 Jun;12 (6):541-8 18852265 - J Biol Chem. 2008 Dec 19;283(51):35845-52 20675376 - J Biol Chem. 2010 Oct 8;285(41):31829-39 17363709 - Circ Res. 2007 Mar 16;100(5):633-44 19801679 - J Biol Chem. 2009 Nov 27;284(48):33671-82 16614312 - Circ Res. 2006 Apr 14;98(7):868-78 8808973 - J Vasc Surg. 1996 Sep;24(3):487-93 2253873 - Genes Dev. 1990 Sep;4(9):1454-61 24068960 - PLoS Genet. 2013;9(9):e1003793 18309114 - Arterioscler Thromb Vasc Biol. 2008 Jun;28(6):1084-9 15231515 - Arterioscler Thromb Vasc Biol. 2004 Sep;24(9):1596-601 18557893 - Neurogastroenterol Motil. 2008 Jul;20(7):829-42 15321943 - Circ Res. 2004 Aug 20;95(4):340-2 23142384 - Gene. 2013 Jan 15;513(1):82-9 20799856 - Stem Cells Dev. 2011 Feb;20(2):205-10 24578380 - Arterioscler Thromb Vasc Biol. 2014 Jun;34(6):1249-59 24077167 - Circulation. 2013 Oct 29;128(18):2047-57 7690144 - Proc Natl Acad Sci U S A. 1993 Sep 1;90(17 ):8145-9 20089806 - J Pharmacol Exp Ther. 2010 Apr;333(1):34-42 18035064 - Biochim Biophys Acta. 2007 Dec;1772(11-12):1250-7 8663449 - J Biol Chem. 1996 Jul 19;271(29):17354-9 19251841 - Am J Physiol Lung Cell Mol Physiol. 2009 May;296(5):L780-9 23671695 - PLoS One. 2013 May 06;8(5):e63721 25301554 - Biochem Biophys Res Commun. 2014 Oct 6;:null 20059958 - Dev Cell. 2009 Dec;17 (6):892-9 15352164 - J Cell Biochem. 2004 Sep 1;93(1):74-82 18028454 - Clin Genet. 2008 Jan;73(1):71-8 19776005 - J Biol Chem. 2009 Dec 4;284(49):33789-94 18005871 - Cardiovasc Pathol. 2007 Nov-Dec;16(6):329-35 17292825 - Cancer Cell. 2007 Feb;11(2):133-46 17379839 - Arterioscler Thromb Vasc Biol. 2007 Jun;27(6):1248-58 21950552 - Andrologia. 2012 May;44 Suppl 1:518-22 22843699 - Cardiovasc Res. 2012 Oct 1;96(1):120-9 8575061 - Circ Res. 1996 Feb;78(2):188-95 16395403 - J Clin Invest. 2006 Jan;116(1):36-48 18188448 - J Clin Invest. 2008 Feb;118(2):515-25 23554919 - PLoS One. 2013;8(3):e58746 10328110 - J Natl Cancer Inst. 1999 May 5;91(9):790-6 12663482 - Circ Res. 2003 May 2;92(8):856-64 23093573 - Circ Res. 2013 Jan 4;112(1):17-22 108688 - Physiol Rev. 1979 Jan;59(1):1-61 19002260 - PLoS One. 2008;3(11):e3707 20068148 - Cancer Res. 2010 Jan 15;70(2):501-11 20458751 - J Cell Physiol. 2010 Nov;225(2):506-11 17222214 - Int J Exp Pathol. 2006 Dec;87(6):463-74 9778514 - Development. 1998 Nov;125(22):4565-74 19541842 - Am J Respir Cell Mol Biol. 2010 Apr;42(4):506-13 22048062 - Nat Rev Neurosci. 2011 Nov 03;12(12):723-38 20167605 - J Biol Chem. 2010 Apr 16;285(16):11800-9 15673566 - Development. 2005 Mar;132(5):987-97 16141410 - Circ Res. 2005 Sep 30;97(7):645-54 23526547 - J Cell Physiol. 2013 Oct;228(10 ):1989-95 20848417 - Head Neck. 2011 Jan;33(1):54-9 15269336 - Physiol Rev. 2004 Jul;84(3):767-801 9624159 - J Biol Chem. 1998 Jun 19;273(25):15654-60 3884359 - Exp Mol Pathol. 1985 Apr;42(2):139-62 23855625 - J Biomed Sci. 2013 Jul 15;20:50 19720868 - Genes Dev. 2009 Sep 15;23(18):2166-78 24060351 - Biochim Biophys Acta. 2013 Nov;1829(11):1191-201 16918817 - J Intern Med. 2006 Sep;260(3):192-210 19956253 - Nature. 2009 Dec 3;462(7273):587-94 20511232 - J Biol Chem. 2010 Jul 23;285(30):23177-85 22028870 - PLoS One. 2011;6(10):e26392 22937150 - PLoS One. 2012;7(8):e44052 22592762 - Int J Impot Res. 2012 Sep;24(5):196-201 16778073 - Genes Dev. 2006 Jun 15;20(12):1545-56 21109779 - EMBO Rep. 2011 Jan;12(1):56-62 21402709 - J Biol Chem. 2011 Apr 29;286(17 ):15050-7 15601857 - Mol Cell Biol. 2005 Jan;25(1):364-76 17101795 - Mol Cell Biol. 2007 Jan;27(2):622-32 21832838 - J Vasc Res. 2011;48(6):485-94 17916802 - Stem Cells. 2008 Jan;26(1):202-11 |
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| Snippet | Myocardin （MYOCD） is a potent transcriptional coactivator that functions primarily in cardiac muscle and smooth muscle through direct contacts with serum... Myocardin (MYOCD) is a potent transcriptional coactivator that functions primarily in cardiac muscle and smooth muscle through direct contacts with serum... |
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| SubjectTerms | Review 基因表达 心肌素 激活因子 生物 细胞骨架 翻译后加工 蛋白复合物 血管性疾病 |
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| Title | Myocardin in biology and disease |
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| Volume | 29 |
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