Correlation between LRP1B Mutations and Tumor Mutation Burden in Gastric Cancer

Background. It has been shown that low-density lipoprotein receptor-related protein 1B (LRP1B) mutations correlate with tumor mutation burden (TMB) and prognosis in patients with melanoma and non-small-cell lung cancer, while the relationship between LRP1B mutations and TMB in gastric cancer needs f...

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Published inComputational and mathematical methods in medicine Vol. 2021; pp. 1522250 - 6
Main Authors Hu, Sizhe, Zhao, Xiaokang, Qian, Feng, Jin, Cancan, Hou, Kaishun
Format Journal Article
LanguageEnglish
Published United States Hindawi 2021
Subjects
Biomarkers, Tumor - genetics
CA-125 Antigen - genetics
Computational Biology
Databases, Genetic
Female
Gene Frequency
Genes, p53
Humans
Male
Membrane Proteins - genetics
Middle Aged
Mutation
Prognosis
Receptors, LDL - genetics
Stomach Neoplasms - genetics
Stomach Neoplasms - pathology
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Summary:Background. It has been shown that low-density lipoprotein receptor-related protein 1B (LRP1B) mutations correlate with tumor mutation burden (TMB) and prognosis in patients with melanoma and non-small-cell lung cancer, while the relationship between LRP1B mutations and TMB in gastric cancer needs further study. This study is aimed at exploring the relationship between LRP1B mutations and TMB in gastric cancer. Methods. Mutation frequency profiles of the genes in patients with gastric cancer in TCGA-STAD dataset were analyzed by bioinformatics analysis. The relationship among LRP1B mutations, TMB, and patient clinical features in gastric cancer was investigated by the chi-square test. The TMB prediction capacity based on LRP1B mutation status was evaluated by ROC curves. Results. LRP1B is one of the top 10 genes with high gene mutation frequency in gastric cancer. The mutation status of LRP1B in gastric cancer patients was significantly correlated with age and TP53 and MUC16 mutation status. The result of ROC curve analysis revealed that the mutation status of LRP1B could be considered as an indicator of the degree of TMB in patients with gastric cancer. Conclusion. This study presented the relationship between TMB and LRP1B mutations in gastric cancer, providing a novel perspective for gastric cancer prognosis and therapy.
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Academic Editor: Tao Huang
ISSN:1748-670X
1748-6718
1748-6718
DOI:10.1155/2021/1522250