Imbalance of Gut Streptococcus , Clostridium , and Akkermansia Determines the Natural Course of Atopic Dermatitis in Infant

The roles of gut microbiota on the natural course of atopic dermatitis (AD) are not yet fully understood. We investigated whether the composition and function of gut microbiota and short-chain fatty acids (SCFAs) at 6 months of age could affect the natural course of AD up to 24 months in early child...

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Published inAllergy, asthma & immunology research Vol. 12; no. 2; pp. 322 - 337
Main Authors Park, Yoon Mee, Lee, So-Yeon, Kang, Mi-Jin, Kim, Bong-Soo, Lee, Min-Jung, Jung, Sung Su, Yoon, Ji Sun, Cho, Hyun-Ju, Lee, Eun, Yang, Song-I, Seo, Ju-Hee, Kim, Hyo-Bin, Suh, Dong In, Shin, Youn Ho, Kim, Kyung Won, Ahn, Kangmo, Hong, Soo-Jong
Format Journal Article
LanguageEnglish
Published Korea (South) Korean Academy of Asthma, Allergy and Clinical Immunology 01.03.2020
The Korean Academy of Asthma, Allergy and Clinical Immunology; The Korean Academy of Pediatric Allergy and Respiratory Disease
대한천식알레르기학회
Subjects
Allergic diseases
Asthma
Atopic dermatitis
Children
Clostridium
Cocoa
Composition
Correlation analysis
Dermatitis
Fatty acids
Gas chromatography
Infants
Intestinal microflora
Mass spectrometry
Mass spectroscopy
Metabolites
Microbiomes
Microbiota
Microorganisms
Original
Oxidative phosphorylation
Phosphorylation
Relative abundance
Streptococcus
내과학
metagenome
infant
metabolomics
Dermatitis, atopic
gastrointestinal microbiome
Online AccessGet full text
ISSN2092-7355
2092-7363
DOI10.4168/aair.2020.12.2.322

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Abstract The roles of gut microbiota on the natural course of atopic dermatitis (AD) are not yet fully understood. We investigated whether the composition and function of gut microbiota and short-chain fatty acids (SCFAs) at 6 months of age could affect the natural course of AD up to 24 months in early childhood. Fecal samples from 132 infants were analyzed using pyrosequencing, including 84 healthy controls, 22 transient AD and 26 persistent AD subjects from the Cohort for Childhood Origin of Asthma and Allergic Diseases (COCOA) birth cohort. The functional profile of the gut microbiome was analyzed by whole-metagenome sequencing. SCFAs were measured using gas chromatography-mass spectrometry. Low levels of and high amounts of were evident in transient AD cases, and low , and high were found in children with persistent AD. The relative abundance of positively correlated with scoring of AD (SCORAD) score, whereas that of negatively correlated with SCORAD score. The persistent AD group showed decreased gut microbial functional genes related to oxidative phosphorylation compared with healthy controls. Butyrate and valerate levels were lower in transient AD infants compared with healthy and persistent AD infants. Compositions, functions and metabolites of the early gut microbiome are related to natural courses of AD in infants.
AbstractList Purpose: The roles of gut microbiota on the natural course of atopic dermatitis (AD) are not yet fully understood. We investigated whether the composition and function of gut microbiota and short-chain fatty acids (SCFAs) at 6 months of age could affect the natural course of AD up to 24 months in early childhood. Methods: Fecal samples from 132 infants were analyzed using pyrosequencing, including 84 healthy controls, 22 transient AD and 26 persistent AD subjects from the Cohort for Childhood Origin of Asthma and Allergic Diseases (COCOA) birth cohort. The functional profile of the gut microbiome was analyzed by whole-metagenome sequencing. SCFAs were measured using gas chromatography-mass spectrometry. Results: Low levels of Streptococcus and high amounts of Akkermansia were evident in transient AD cases, and low Clostridium, Akkermansia and high Streptococcus were found in children with persistent AD. The relative abundance of Streptococcus positively correlated with scoring of AD (SCORAD) score, whereas that of Clostridium negatively correlated with SCORAD score. The persistent AD group showed decreased gut microbial functional genes related to oxidative phosphorylation compared with healthy controls. Butyrate and valerate levels were lower in transient AD infants compared with healthy and persistent AD infants. Conclusions: Compositions, functions and metabolites of the early gut microbiome are related to natural courses of AD in infants. KCI Citation Count: 1
The roles of gut microbiota on the natural course of atopic dermatitis (AD) are not yet fully understood. We investigated whether the composition and function of gut microbiota and short-chain fatty acids (SCFAs) at 6 months of age could affect the natural course of AD up to 24 months in early childhood.PURPOSEThe roles of gut microbiota on the natural course of atopic dermatitis (AD) are not yet fully understood. We investigated whether the composition and function of gut microbiota and short-chain fatty acids (SCFAs) at 6 months of age could affect the natural course of AD up to 24 months in early childhood.Fecal samples from 132 infants were analyzed using pyrosequencing, including 84 healthy controls, 22 transient AD and 26 persistent AD subjects from the Cohort for Childhood Origin of Asthma and Allergic Diseases (COCOA) birth cohort. The functional profile of the gut microbiome was analyzed by whole-metagenome sequencing. SCFAs were measured using gas chromatography-mass spectrometry.METHODSFecal samples from 132 infants were analyzed using pyrosequencing, including 84 healthy controls, 22 transient AD and 26 persistent AD subjects from the Cohort for Childhood Origin of Asthma and Allergic Diseases (COCOA) birth cohort. The functional profile of the gut microbiome was analyzed by whole-metagenome sequencing. SCFAs were measured using gas chromatography-mass spectrometry.Low levels of Streptococcus and high amounts of Akkermansia were evident in transient AD cases, and low Clostridium, Akkermansia and high Streptococcus were found in children with persistent AD. The relative abundance of Streptococcus positively correlated with scoring of AD (SCORAD) score, whereas that of Clostridium negatively correlated with SCORAD score. The persistent AD group showed decreased gut microbial functional genes related to oxidative phosphorylation compared with healthy controls. Butyrate and valerate levels were lower in transient AD infants compared with healthy and persistent AD infants.RESULTSLow levels of Streptococcus and high amounts of Akkermansia were evident in transient AD cases, and low Clostridium, Akkermansia and high Streptococcus were found in children with persistent AD. The relative abundance of Streptococcus positively correlated with scoring of AD (SCORAD) score, whereas that of Clostridium negatively correlated with SCORAD score. The persistent AD group showed decreased gut microbial functional genes related to oxidative phosphorylation compared with healthy controls. Butyrate and valerate levels were lower in transient AD infants compared with healthy and persistent AD infants.Compositions, functions and metabolites of the early gut microbiome are related to natural courses of AD in infants.CONCLUSIONSCompositions, functions and metabolites of the early gut microbiome are related to natural courses of AD in infants.
The roles of gut microbiota on the natural course of atopic dermatitis (AD) are not yet fully understood. We investigated whether the composition and function of gut microbiota and short-chain fatty acids (SCFAs) at 6 months of age could affect the natural course of AD up to 24 months in early childhood. Fecal samples from 132 infants were analyzed using pyrosequencing, including 84 healthy controls, 22 transient AD and 26 persistent AD subjects from the Cohort for Childhood Origin of Asthma and Allergic Diseases (COCOA) birth cohort. The functional profile of the gut microbiome was analyzed by whole-metagenome sequencing. SCFAs were measured using gas chromatography-mass spectrometry. Low levels of and high amounts of were evident in transient AD cases, and low , and high were found in children with persistent AD. The relative abundance of positively correlated with scoring of AD (SCORAD) score, whereas that of negatively correlated with SCORAD score. The persistent AD group showed decreased gut microbial functional genes related to oxidative phosphorylation compared with healthy controls. Butyrate and valerate levels were lower in transient AD infants compared with healthy and persistent AD infants. Compositions, functions and metabolites of the early gut microbiome are related to natural courses of AD in infants.
Purpose The roles of gut microbiota on the natural course of atopic dermatitis (AD) are not yet fully understood. We investigated whether the composition and function of gut microbiota and short-chain fatty acids (SCFAs) at 6 months of age could affect the natural course of AD up to 24 months in early childhood. Methods Fecal samples from 132 infants were analyzed using pyrosequencing, including 84 healthy controls, 22 transient AD and 26 persistent AD subjects from the Cohort for Childhood Origin of Asthma and Allergic Diseases (COCOA) birth cohort. The functional profile of the gut microbiome was analyzed by whole-metagenome sequencing. SCFAs were measured using gas chromatography-mass spectrometry. Results Low levels of Streptococcus and high amounts of Akkermansia were evident in transient AD cases, and low Clostridium, Akkermansia and high Streptococcus were found in children with persistent AD. The relative abundance of Streptococcus positively correlated with scoring of AD (SCORAD) score, whereas that of Clostridium negatively correlated with SCORAD score. The persistent AD group showed decreased gut microbial functional genes related to oxidative phosphorylation compared with healthy controls. Butyrate and valerate levels were lower in transient AD infants compared with healthy and persistent AD infants. Conclusions Compositions, functions and metabolites of the early gut microbiome are related to natural courses of AD in infants.
Author Lee, Min-Jung
Seo, Ju-Hee
Kang, Mi-Jin
Kim, Hyo-Bin
Yang, Song-I
Shin, Youn Ho
Kim, Bong-Soo
Suh, Dong In
Kim, Kyung Won
Yoon, Ji Sun
Lee, So-Yeon
Cho, Hyun-Ju
Park, Yoon Mee
Jung, Sung Su
Ahn, Kangmo
Lee, Eun
Hong, Soo-Jong
AuthorAffiliation 8 Department of Pediatrics, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Korea
1 Asan Institute for Life Sciences, Asan Medical Center, Seoul, Korea
10 Department of Pediatrics, Dankuk University Hospital, Cheonan, Korea
13 Department of Pediatrics, CHA Gangnam Medical Center, CHA University School of Medicine, Seoul, Korea
11 Department of Pediatrics, Inje University Sanggye Paik Hospital, Seoul, Korea
15 Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
12 Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea
7 Department of Pediatrics, International St. Mary's Hospital, Catholic Kwandong University College of Medicine, Incheon, Korea
4 Department of Life Science, Multidisciplinary Genome Institute, Hallym University, Chuncheon, Korea
5 Department of Pediatrics, Pusan National University Yangsan Hospital, Yangsan, Korea
6 Department of Pediatrics, Mediplex Sejo
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– name: 9 Department of Pediatrics, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea
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  surname: Yang
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  surname: Kim
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  organization: Department of Pediatrics, Yonsei University of Medicine, Seoul, Korea
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  orcidid: 0000-0001-7751-9829
  surname: Ahn
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  surname: Hong
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  organization: Department of Pediatrics, Childhood Asthma Atopy Center, Environmental Health Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
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ContentType Journal Article
Copyright Copyright © 2020 The Korean Academy of Asthma, Allergy and Clinical Immunology · The Korean Academy of Pediatric Allergy and Respiratory Disease.
Copyright Korean Academy of Asthma, Allergy and Clinical Immunology Mar 2020
Copyright © 2020 The Korean Academy of Asthma, Allergy and Clinical Immunology • The Korean Academy of Pediatric Allergy and Respiratory Disease 2020 The Korean Academy of Asthma, Allergy and Clinical Immunology • The Korean Academy of Pediatric Allergy and Respiratory Disease
Copyright_xml – notice: Copyright © 2020 The Korean Academy of Asthma, Allergy and Clinical Immunology · The Korean Academy of Pediatric Allergy and Respiratory Disease.
– notice: Copyright Korean Academy of Asthma, Allergy and Clinical Immunology Mar 2020
– notice: Copyright © 2020 The Korean Academy of Asthma, Allergy and Clinical Immunology • The Korean Academy of Pediatric Allergy and Respiratory Disease 2020 The Korean Academy of Asthma, Allergy and Clinical Immunology • The Korean Academy of Pediatric Allergy and Respiratory Disease
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Issue 2
Keywords metagenome
infant
metabolomics
Dermatitis, atopic
gastrointestinal microbiome
Language English
License Copyright © 2020 The Korean Academy of Asthma, Allergy and Clinical Immunology · The Korean Academy of Pediatric Allergy and Respiratory Disease.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Snippet The roles of gut microbiota on the natural course of atopic dermatitis (AD) are not yet fully understood. We investigated whether the composition and function...
Purpose The roles of gut microbiota on the natural course of atopic dermatitis (AD) are not yet fully understood. We investigated whether the composition and...
Purpose: The roles of gut microbiota on the natural course of atopic dermatitis (AD) are not yet fully understood. We investigated whether the composition and...
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SubjectTerms Allergic diseases
Asthma
Atopic dermatitis
Children
Clostridium
Cocoa
Composition
Correlation analysis
Dermatitis
Fatty acids
Gas chromatography
Infants
Intestinal microflora
Mass spectrometry
Mass spectroscopy
Metabolites
Microbiomes
Microbiota
Microorganisms
Original
Oxidative phosphorylation
Phosphorylation
Relative abundance
Streptococcus
내과학
Title Imbalance of Gut Streptococcus , Clostridium , and Akkermansia Determines the Natural Course of Atopic Dermatitis in Infant
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