Imbalance of Gut Streptococcus , Clostridium , and Akkermansia Determines the Natural Course of Atopic Dermatitis in Infant

• Published in: Allergy, asthma & immunology research Vol. 12; no. 2; pp. 322 - 337
• Main Authors: Park, Yoon Mee, Lee, So-Yeon, Kang, Mi-Jin, Kim, Bong-Soo, Lee, Min-Jung, Jung, Sung Su, Yoon, Ji Sun, Cho, Hyun-Ju, Lee, Eun, Yang, Song-I, Seo, Ju-Hee, Kim, Hyo-Bin, Suh, Dong In, Shin, Youn Ho, Kim, Kyung Won, Ahn, Kangmo, Hong, Soo-Jong
• Format: Journal Article
• Language: English
• Published: Korea (South) Korean Academy of Asthma, Allergy and Clinical Immunology 01.03.2020; The Korean Academy of Asthma, Allergy and Clinical Immunology; The Korean Academy of Pediatric Allergy and Respiratory Disease; 대한천식알레르기학회
• Subjects: Allergic diseases; Asthma; Atopic dermatitis; Children; Clostridium; Cocoa; Composition; Correlation analysis; Dermatitis; Fatty acids; Gas chromatography; Infants; Intestinal microflora; Mass spectrometry; Mass spectroscopy; Metabolites; Microbiomes; Microbiota; Microorganisms; Original; Oxidative phosphorylation; Phosphorylation; Relative abundance; Streptococcus; 내과학; metagenome; infant; metabolomics; Dermatitis, atopic; gastrointestinal microbiome
• ISSN: 2092-7355; 2092-7363
• DOI: 10.4168/aair.2020.12.2.322

The roles of gut microbiota on the natural course of atopic dermatitis (AD) are not yet fully understood. We investigated whether the composition and function of gut microbiota and short-chain fatty acids (SCFAs) at 6 months of age could affect the natural course of AD up to 24 months in early childhood. Fecal samples from 132 infants were analyzed using pyrosequencing, including 84 healthy controls, 22 transient AD and 26 persistent AD subjects from the Cohort for Childhood Origin of Asthma and Allergic Diseases (COCOA) birth cohort. The functional profile of the gut microbiome was analyzed by whole-metagenome sequencing. SCFAs were measured using gas chromatography-mass spectrometry. Low levels of and high amounts of were evident in transient AD cases, and low , and high were found in children with persistent AD. The relative abundance of positively correlated with scoring of AD (SCORAD) score, whereas that of negatively correlated with SCORAD score. The persistent AD group showed decreased gut microbial functional genes related to oxidative phosphorylation compared with healthy controls. Butyrate and valerate levels were lower in transient AD infants compared with healthy and persistent AD infants. Compositions, functions and metabolites of the early gut microbiome are related to natural courses of AD in infants.