Advantages of laparoscopic resection for ileocecal Crohn's disease

• Published in: Diseases of the colon & rectum Vol. 45; no. 5; pp. 605 - 610
• Main Authors: DUEPREE, Hans-Joachim, SENAGORE, Anthony J, DELANEY, Conor P, BRADY, Karen M, FAZIO, Victor W
• Format: Conference Proceeding Journal Article
• Language: English
• Published: Secaucus, NJ Springer 01.05.2002; Lippincott Williams & Wilkins Ovid Technologies
• Subjects: Adult; Biological and medical sciences; Cecum - surgery; Cohort Studies; Costs and Cost Analysis; Crohn Disease - economics; Crohn Disease - surgery; Female; Humans; Intestinal Obstruction - surgery; Laparoscopy - economics; Laparoscopy - methods; Male; Medical sciences; Middle Aged; Postoperative Complications; Statistics, Nonparametric; Stomach, duodenum, intestine, rectum, anus; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgery of the digestive system; Treatment Outcome; Human; Endoscopic surgery; Surgical resection; Laparoscopy; Cost benefit analysis; Inflammatory disease; Crohn disease; Treatment; Health economy; Digestive diseases; Intestinal disease; Ileocecal; Public health; Comparative study
• ISSN: 0012-3706; 1530-0358
• DOI: 10.1007/s10350-004-6253-6

Elective laparoscopic-assisted resection of terminal ileal Crohn's disease is slowly gaining acceptance as an alternative to conventional surgery, based on the advantages of earlier return of bowel function, reductions in length of stay, and smaller wounds in a population likely to require reoperation. There is limited documentation of the cost-effectiveness of this approach, particularly with the reported longer operating times. The purpose of this study was to compare laparoscopic and open resections for terminal ileal Crohn's disease. We compared contemporaneous cohorts of patients undergoing initial elective laparoscopic or open resection for ileocecal Crohn's disease between June 1, 1999 and October 31, 2000 at a single institution. Operative approach was at the discretion of the surgeon. Data collected included age, gender, body mass index, American Society of Anesthesiologists score, indication for surgery, morbidity, mortality, conversion (laparoscopic-resection group only), operating-room time, length of hospital stay, direct cost per case, 30-day readmission, and return to work. All data are presented as medians and interquartile ranges. Data analysis was performed with the Mann-Whitney U test, Fisher's exact test, and Student's t-test where appropriate. Significance was set at P < 0.05. There were 45 evaluable patients (laparoscopic-resection group, 21; open-resection group, 24). One procedure was considered a conversion because of the 13-cm incision required to exteriorize the phlegmon (conversion rate, 4.8 percent). The median age (laparoscopic-resection group, 31 years; open-resection group, 39 years) and gender distributions (male/female: laparoscopic-resection group, 129; open-resection group, 915) were significantly different between the two groups. Resumption of oral intake (operating-room day vs. second postoperative day; P < 0.05) and resumption of intestinal function (2 vs. 4 days; P < 0.05) were significantly faster in the laparoscopic-resection patients. The median length of hospital stay was significantly shorter for the laparoscopic-resection patients (3 (2-3) vs. 5 (4-6) days; P < 0.05). The 30-day readmission rate in the laparoscopic-resection group was 9.6 percent (221), whereas none of the open-resection patients required rehospitalization. The overall complication rates were comparable for the laparoscopic-resection and open-resection patients (14.3 vs. 16.7 percent; P not significant), although there was one anastomotic leak and one intra-abdominal abscess in the laparoscopic-resection group, requiring readmission and reintervention (9.6 percent; P not significant). The direct cost per case was significantly lower for the laparoscopic-resection group ($2,547 vs. $2,985; P < 0.05, Student's t-test). The laparoscopic-assisted approach to ileocecal Crohn's disease results in a shortened length of stay and seems economically advantageous to open surgery.