In Vitro Elution of Vancomycin from Calcium Phosphate Cement

• Published in: The Journal of arthroplasty Vol. 20; no. 8; pp. 1055 - 1059
• Main Authors: Sasaki, Tomoyuki, Ishibashi, Yasuyuki, Katano, Hiroshi, Nagumo, Akira, Toh, Satoshi
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.12.2005
• Subjects: Adult; Anti-Bacterial Agents - administration & dosage; Anti-Bacterial Agents - pharmacokinetics; Anti-Bacterial Agents - pharmacology; antibiotic-impregnated bone cement; Bone Cements; calcium phosphate cement; Calcium Phosphates; Female; Hip Prosthesis; Humans; In Vitro Techniques; osteomyelitis; Osteomyelitis - drug therapy; Osteomyelitis - etiology; prosthesis infection; Prosthesis-Related Infections - drug therapy; vancomycin; Vancomycin - administration & dosage; Vancomycin - pharmacokinetics; Vancomycin - pharmacology; osteomyelitis; prosthesis infection; vancomycin; antibiotic-impregnated bone cement; calcium phosphate cement
• ISSN: 0883-5403; 1532-8406
• DOI: 10.1016/j.arth.2005.03.035

Antibiotic-impregnated bone cement beads have become popular for the treatment of osteomyelitis and/or prosthesis infection. However, bone cement has the disadvantage of heating up during polymerization of cement. Recently, calcium phosphate cement (CPC) has been used as a bone replacement and augmentation, and it does not heat up during polymerization. First, we measured the release rate of vancomycin (VCM) from bone cement and CPC impregnated with VCM for 2 weeks in vitro. The mean concentration of VCM for CPC was 62.6 times at 7 days (258 ± 29 vs 4.12 ± 1.0) and 6.7 times at 13 days (15.5 ± 5.5 vs 2.3 ± 0.7). Second, we were successful in treating 2 cases of osteomyelitis and prosthesis infection with VCM-impregnated CPC. From this study, we concluded that VCM-impregnated CPC might be an effective material for the treatment of osteomyelitis and/or prosthesis infection.