Severity of diabetic retinopathy is associated with left ventricular diastolic dysfunction in patients with type 2 diabetes

• Published in: Diabetes research and clinical practice Vol. 99; no. 3; pp. 287 - 291
• Main Authors: Kurioka, Soichi, Ose, Hiroyuki, Fukuma, Kazuhiro, Yoshimoto, Keisuke
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 01.03.2013
• Subjects: Aged; Diabetes Mellitus, Type 2 - complications; Diabetic retinopathy; Diabetic Retinopathy - physiopathology; Diastole - physiology; Diastolic dysfunction; Echocardiography; Echocardiography, Doppler; Endocrinology & Metabolism; Female; Humans; Male; Regression Analysis; Ventricular Dysfunction, Left - physiopathology; T2DM; heart failure; left ventricular diastolic dysfunction; Echocardiography; type 2 diabetes mellitus; LVEF; LVDD; Diastolic dysfunction; diabetic retinopathy; DR; left ventricular ejection fraction; HF; Diabetic retinopathy
• ISSN: 0168-8227; 1872-8227
• DOI: 10.1016/j.diabres.2012.12.021

Abstract Aim The aim of the study was to examine the association of severity of diabetic retinopathy (DR) with left ventricular diastolic dysfunction (LVDD). Methods The subjects were 120 patients with type 2 diabetes mellitus (T2DM). All patients underwent clinical evaluation, laboratory tests, and echocardiographic examination. Doppler echocardiographic indices including peak early diastolic mitral annular velocity (e′) and early diastolic myocardial velocity (E) were obtained in each patient. Results The patients were divided into three groups based on the presence and severity of DR: no DR ( n = 80), simple DR ( n = 20), and preproliferative or proliferative DR ( n = 20). No patients showed systolic impairment of left ventricular ejection fraction (LVEF > 50%), whereas impaired LV diastolic function (E/e′ > 8) occurred in 104 cases (87%) and LVDD (E/e′ > 15) was detected in 19 cases (16%). E/e′ was correlated with age, sex, diabetic duration, DR stage, systolic blood pressure, and serum creatinine level. In multiple regression analysis, age ( β = 0.322, p < 0.001) and DR stage ( β = 0.266, p = 0.002) were independently correlated with E/e′. Conclusions The results of the study show that almost all subjects had asymptomatic LVDD and that the severity of DR was associated with LVDD in patients with T2DM.