High incidence of anal high-grade squamous intra-epithelial lesions among HIV-positive and HIV-negative homosexual and bisexual men

• Published in: AIDS (London) Vol. 12; no. 5; pp. 495 - 503
• Main Authors: PALEFSKY, J. M, HOLLY, E. A, RALSTON, M. L, JAY, N, BERRY, J. M, DARRAGH, T. M
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 26.03.1998
• Subjects: AIDS/HIV; Anal Canal - pathology; Anal Canal - virology; Anus Neoplasms - epidemiology; Anus Neoplasms - etiology; Anus Neoplasms - pathology; Biological and medical sciences; Bisexuality; Carcinoma in Situ - epidemiology; Carcinoma in Situ - etiology; Carcinoma in Situ - pathology; CD4 Lymphocyte Count; Gastroenterology. Liver. Pancreas. Abdomen; HIV Infections - complications; Homosexuality, Male; Humans; Incidence; Interviews as Topic; Male; Medical sciences; Neoplasms, Squamous Cell - epidemiology; Neoplasms, Squamous Cell - etiology; Neoplasms, Squamous Cell - pathology; Papillomaviridae; Papillomavirus Infections - complications; Polymerase Chain Reaction; Prospective Studies; Risk Factors; San Francisco; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Surveys and Questionnaires; Time Factors; Tumors; San Francisco; Human; Immunopathology; Homosexuality; Sexual behavior; Male; AIDS; Papovaviridae; Bisexuality; Malignant tumor; Immune deficiency; Incidence; Squamous metaplasia; Infection; Papillomavirus; Virus; Human papillomavirus; Anus; Viral disease; Risk factor; Digestive diseases; Anorectal disease
• ISSN: 0269-9370; 1473-5571
• DOI: 10.1097/00002030-199805000-00011

The incidence of anal cancer among homosexual men exceeds that of cervical cancer in women, and HIV-positive homosexual men may be at even higher risk than HIV-negative men. Cervical cancer is preceded by high-grade squamous intra-epithelial lesions (HSIL) and anal HSIL may similarly be the precursor to anal cancer. In this study, we describe the incidence of and risk factors for HSIL in HIV-positive and HIV-negative homosexual and bisexual men. Prospective cohort study of HIV-positive and HIV-negative homosexual men. The University of California, San Francisco. 346 HIV-positive and 262 HIV-negative men enrolled at baseline, 277 HIV-positive and 221 HIV-negative homosexual men followed after baseline. A questionnaire was administered detailing lifestyle habits, medical history and sexual practices. Anal swabs for cytology and human papillomavirus studies were obtained, followed by biopsies of visible lesions. Human papillomavirus testing was performed using polymerase chain reaction (PCR) and 'hybrid capture'. Blood was obtained for HIV testing and measurement of CD4 levels. Incident HSIL. HIV-positive men were more likely to develop HSIL than HIV-negative men relative risk (RR), 3.7; 95% confidence interval (CI), 2.6-5.7. Life-table estimates of the 4-year incidence of HSIL was 49% (95% CI, 41-56) among HIV-positive men and 17% (95% CI, 12-23) among HIV-negative men. Among HIV-positive men, those with lower baseline CD4 counts (P = 0.007) and persistent infection with one or more human papillomavirus types, determined using PCR (P = 0.0001), were more likely to develop HSIL. HIV infection, lower CD4 levels and human papillomavirus infection were associated with high rates of incident HSIL among homosexual men. However, high rates were found at all CD4 levels among HIV-positive men and among HIV-negative men.