Effect of long-term potentiation induction on gamma-band electroencephalograms in prefrontal cortex following stimulation of rat hippocampus in vivo

• Published in: Neuroscience letters Vol. 305; no. 1; pp. 57 - 60
• Main Authors: Izaki, Yoshinori, Takita, Masatoshi, Jay, Thérèse M, Kaneko, Hidekazu, Suzuki, Shinya S, Nomura, Masahiko
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 01.06.2001; Elsevier
• Subjects: Anesthesia; Animals; Biological and medical sciences; Central nervous system; Electric Stimulation; Electroencephalogram; Electroencephalography; Electrophysiology; Field potential; Fundamental and applied biological sciences. Psychology; Hippocampus; Long-term potentiation; Long-Term Potentiation - physiology; Male; Prefrontal cortex; Prefrontal Cortex - physiology; Rat; Rats; Rats, Sprague-Dawley; Reaction Time - physiology; Synaptic Transmission - physiology; Vertebrates: nervous system and sense organs; Electroencephalogram; Rat; Long-term potentiation; Field potential; Anesthesia; Prefrontal cortex; Electric stimulation; Hippocampus; Potentiation; Gamma rhythm; Electrical stimulus; Rodentia; Central nervous system; Electroencephalography; Long term; Vertebrata; Mammalia; Synaptic transmission; Brain (vertebrata)
• ISSN: 0304-3940; 1872-7972
• DOI: 10.1016/S0304-3940(01)01807-9

We examined whether long-term potentiation (LTP) affects cortical gamma-band electroencephalograms (EEG) in the hippocampo-prefrontal cortex (PFC) pathway of anesthetized rats. The LTP induction increased the evoked PFC gamma-band EEG power (40–100 Hz) to 120–135% at 500–700 ms after test stimulation. A simple increment of stimulus intensity, instead of LTP induction, did not reveal this evoked increase. Neither LTP induction nor the intensity increment changed significantly the magnitude of an evoked decrease at around 100 ms or the spontaneous prestimulation gamma-band power. These results indicate that LTP in PFC specifically increases the evoked gamma-band EEG power, which may reflect a phasic mode of plastic neurotransmission through the hippocampo-PFC pathway in vivo.