Challenges Associated With Applying Physiologically Based Pharmacokinetic Modeling for Public Health Decision-Making

• Published in: Toxicological sciences Vol. 162; no. 2; pp. 341 - 348
• Main Authors: Tan, Yu-Mei, Worley, Rachel R, Leonard, Jeremy A, Fisher, Jeffrey W
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.04.2018
• Subjects: Decision Making; Decision Support Techniques; Government Agencies; Humans; Models, Biological; Pharmacokinetics; Public Health - legislation & jurisprudence; Toxicokinetics; Toxicology - methods; United States; United States; intraspecies extrapolation; risk assessment; physiologically based pharmacokinetic model; interspecies extrapolation; good modeling practice
• ISSN: 1096-6080; 1096-0929
• DOI: 10.1093/toxsci/kfy010

Abstract The development and application of physiologically based pharmacokinetic (PBPK) models in chemical toxicology have grown steadily since their emergence in the 1980s. However, critical evaluation of PBPK models to support public health decision-making across federal agencies has thus far occurred for only a few environmental chemicals. In order to encourage decision-makers to embrace the critical role of PBPK modeling in risk assessment, several important challenges require immediate attention from the modeling community. The objective of this contemporary review is to highlight 3 of these challenges, including: (1) difficulties in recruiting peer reviewers with appropriate modeling expertise and experience; (2) lack of confidence in PBPK models for which no tissue/plasma concentration data exist for model evaluation; and (3) lack of transferability across modeling platforms. Several recommendations for addressing these 3 issues are provided to initiate dialog among members of the PBPK modeling community, as these issues must be overcome for the field of PBPK modeling to advance and for PBPK models to be more routinely applied in support of public health decision-making.