Role of protein Post-translational modifications in enterovirus infection
Enteroviruses (EVs) are the main cause of a number of neurological diseases. Growing evidence has revealed that successful infection with enteroviruses is highly dependent on the host machinery, therefore, host proteins play a pivotal role in viral infections. Both host and viral proteins can underg...
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Published in | Frontiers in microbiology Vol. 15; p. 1341599 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
Switzerland
Frontiers Media S.A
26.02.2024
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Subjects | |
Online Access | Get full text |
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Summary: | Enteroviruses (EVs) are the main cause of a number of neurological diseases. Growing evidence has revealed that successful infection with enteroviruses is highly dependent on the host machinery, therefore, host proteins play a pivotal role in viral infections. Both host and viral proteins can undergo post-translational modification (PTM) which can regulate protein activity, stability, solubility and interactions with other proteins; thereby influencing various biological processes, including cell metabolism, metabolic, signaling pathways, cell death, and cancer development. During viral infection, both host and viral proteins regulate the viral life cycle through various PTMs and different mechanisms, including the regulation of host cell entry, viral protein synthesis, genome replication, and the antiviral immune response. Therefore, protein PTMs play important roles in EV infections. Here, we review the role of various host- and virus-associated PTMs during enterovirus infection. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 Mir Mubashir Khalid, Gladstone Institutes, United States Fuminori Tokunaga, Osaka Metropolitan University, Japan Edited by: Leiliang Zhang, Shandong First Medical University and Shandong Academy of Medical Sciences, China Reviewed by: Girish Patil, Oklahoma State University, United States |
ISSN: | 1664-302X 1664-302X |
DOI: | 10.3389/fmicb.2024.1341599 |