Resolution of childhood peanut allergy
Peanut allergy creates great fear in many families because it is one of the leading causes of fatal and near-fatal food-induced allergies. Earlier reports suggested that peanut allergy was life-long, but a recent study described resolution of peanut allergy in some children. Tolerance to peanut alle...
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Published in | Annals of allergy, asthma, & immunology Vol. 85; no. 6 Pt 1; p. 473 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
United States
01.12.2000
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Subjects | |
Online Access | Get more information |
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Summary: | Peanut allergy creates great fear in many families because it is one of the leading causes of fatal and near-fatal food-induced allergies. Earlier reports suggested that peanut allergy was life-long, but a recent study described resolution of peanut allergy in some children.
Tolerance to peanut allergy in childhood was studied. Examination of the natural history of childhood peanut allergy was explored.
A retrospective review of all children with peanut allergy seen at the Children's Hospital of Philadelphia in a 3-year period (n = 293). Children with histories of peanut allergy were challenged at the mean age [3.8 years; range 1.5 to 8 year] which was 1.8 years [range: 0.5 to 6.8 years], following their last known clinical reaction. Food allergy or tolerance was confirmed by open challenges.
Thirty-three patients with histories of peanut allergy and a positive skin test to peanut underwent oral challenges. Not one patient (n = 5) with a history of peanut anaphylaxis developed tolerance to peanuts. In comparison, 9 of 17 patients with history of urticaria upon ingestion to peanuts developed tolerance. Also, 4 of 10 patients with flaring of their atopic dermatitis upon ingestion to peanuts developed tolerance. The 14 patients with a negative challenge to peanut had a significantly smaller wheal and flare reaction than the 19 patients with positive challenges. Tolerance to peanut was documented by a positive challenge reverting to a negative challenge in one patient. Oral challenge of 13 additional patients with positive skin tests and histories of only refusing to eat peanut resulted in 5 (39%) positive challenges.
A selected group of peanut-allergic children, who do not have a history anaphylaxis to peanut, may develop tolerance to peanuts. |
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ISSN: | 1081-1206 |
DOI: | 10.1016/S1081-1206(10)62574-4 |