Prenylated indole-terpenoids with antidiabetic activities from Penicillium sp. HFF16 from the rhizosphere soil of Cynanchum bungei Decne

Finding novel and effective suppression of hepatic glucagon response antidiabetic compounds is urgently required for the development of new drugs against diabetes. Fungi are well known for their ability to produce new bioactive secondary metabolites. In this study, four new prenylated indole-terpeno...

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Published inFrontiers in microbiology Vol. 14; p. 1099103
Main Authors Liu, Xijin, Kong, Fandong, Xiao, Na, Li, Xiaoyu, Zhang, Mingyu, Lv, Fujin, Liu, Xiaolin, Kong, Xiangchuan, Bi, Jing, Lu, Xinyi, Kong, Daqing, Hao, Gangping, Zhou, Liman, Pan, Guojun
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 02.03.2023
Subjects
Antidiabetic activity
Cynanchum bungei Decne
fungus
indole-terpenoids
Microbiology
Penicillium sp. HFF16
indole-terpenoids
fungus
Antidiabetic activity
Cynanchum bungei Decne
Penicillium sp. HFF16
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Summary:Finding novel and effective suppression of hepatic glucagon response antidiabetic compounds is urgently required for the development of new drugs against diabetes. Fungi are well known for their ability to produce new bioactive secondary metabolites. In this study, four new prenylated indole-terpenoids ( ), named encindolenes I-L, as well as a known analogue ( ), were isolated from the fungus sp. HFF16from the rhizosphere soil of Decne. The structures of the compounds were elucidated by spectroscopic data and ECD analysis. In the antidiabetic activity assay, compounds could inhibit glucagon-induced hepatic glucose output with EC values of 67.23, 102.1, 49.46, 25.20, and 35.96 μM, respectively, and decrease the intracellular cAMP contents in primary hepatocytes.
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This article was submitted to Microbial Physiology and Metabolism, a section of the journal Frontiers in Microbiology
These authors have contributed equally to this work
Edited by: Kalindi Morgan, University of Northern British Columbia Canada, Canada
Reviewed by: Erwei Li, Institute of Microbiology (CAS), China; Dewu Zhang, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences, China
ISSN:1664-302X
1664-302X
DOI:10.3389/fmicb.2023.1099103