Polycystic ovary syndrome patients with high BMI tend to have functional disorders of androgen excess： a prospective study

• Published in: Journal of biomedical research Vol. 30; no. 3; pp. 197 - 202
• Main Authors: Yuan, Chun, Liu, Xiaoqiang, Mao, Yundong, Diao, Feiyang, Cui, Yugui, Liu, Jiayin
• Format: Journal Article
• Language: English
• Published: China Editorial Department of Journal of Biomedical Research 01.01.2016
• Subjects: Original; 体重指数; 多囊卵巢综合征; 患者; 模型评估; 疾病; 结合球蛋白; 胰岛素抵抗; 雄激素; diagnostic criteria; long-term weight; reproductive health; obesity; polycystic ovary syndrome
• ISSN: 1674-8301; 2352-4685
• DOI: 10.7555/JBR.30.20140111

Biochemical or clinical changes of hyperandrogenism are important elements of polycystic ovary syndrome （PCOS）. There is currently no consensus on the definition and diagnostic criteria of hyperandrogenism in PCOS. The aim of this study was to investigate the complex symptoms of hyperandrogenic disorders and the correlations between metabolism and hyperandrogenism in patients with PCOS from an outpatient reproductive medicine clinic in China. We conducted a case control study of 125 PCOS patients and 130 controls to evaluate differences in body mass index （BMI）, total testosterone （TT）, modified Ferriman-Gallwey hirsutism score, sex hormone binding globulin （SHBG）, homeostasis model assessment-estimated insulin resistance （HOMA-IR） and free androgen index （FAI） between PCOS patients and controls and subgroups of PCOS. The prevalence of acne and hirsutism did not differ significantly between the hyperandrogenic and non-hyperandrogenic subgroup. Patients with signs of hyper- androgenism had significantly higher BMI （P 〈 0.05）, but differences in TT, SHBG, FAI and waist/hip ratio were insignificant. The odds ratio of overweight was calculated for all PCOS patients. Our results suggest that PCOS patients with high BMI tend to have functional disorders of androgen excess; therefore, BMI may be a strong pre-dictor of hyperandrogenism in PCOS.