Effect of dexmedetomidine on the median effective concentration of ropivacaine for postoperative analgesia in transversus abdominis plane block: an up-down sequential allocation study

• Published in: Frontiers in medicine Vol. 12; p. 1491849
• Main Authors: Ye, Qin, Xu, Hongchun, Liu, Xiao, Wang, Xujiao, Wang, Fangjun
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 28.04.2025
• Subjects: dexmedetomidine; EC50; Medicine; postoperative pain; ropivacaine; transversus abdominis plane block; ropivacaine; EC50; dexmedetomidine; transversus abdominis plane block; postoperative pain
• ISSN: 2296-858X; 2296-858X
• DOI: 10.3389/fmed.2025.1491849

This study aimed to observe the effect of dexmedetomidine on the median effective concentration (EC ) of ropivacaine for postoperative analgesia in ultrasound-guided transversus abdominis plane block. Patients undergoing elective laparoscopic cholecystectomy were randomly divided into the RD group and the R group. In the RD group, 40 mL of ropivacaine with 1 μg/kg dexmedetomidine was injected into the transverse abdominis plane, while subjects in the R group received equal volumes of ropivacaine with normal saline. When the visual analogue scale (VAS) ≤ 3 within 6 h after surgery, postoperative analgesia was assessed as effective. The probit regression was used to calculate the EC and effective concentration in 95% of patients (EC ) of ropivacaine for ultrasound-guided transversus abdominis plane block. The Quality of Recovery-40 (QoR-40) Score on 24 h after surgery and the incidence of adverse reactions were recorded. The EC of ropivacaine calculated by the probit regression was 0.207% (95% CI, 0.188% ~ 0.228%) in the R group and 0.165% (95% CI, 0.146% ~ 0.182%) in the RD group. The EC of ropivacaine was 0.255% (95% CI, 0.230% ~ 0.499%) in the R group and 0.209% (95% CI, 0.187% ~ 0.430%) in the RD group. The score of physical comfort, emotional state, pain, and global score of QoR-40 on 24h after the operation in the RD group was higher than the R group ( =0.036, 0.035, 0.027 and 0.020, respectively). There were no significant differences in the incidence of adverse reactions between the two groups. Dexmedetomidine as a local anesthetic adjuvant can reduce the EC and EC of ropivacaine and improve the quality of postoperative recovery of patients with transversus abdominis plane block.