Importance of timing of preprandial subcutaneous insulin administration in the management of diabetes mellitus
Importance of timing of preprandial subcutaneous insulin administration in the management of diabetes mellitus. G D Dimitriadis and J E Gerich Abstract Since little is known regarding the appropriate time for preprandial insulin administration, we compared the effects of 30-min subcutaneous insulin...
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Published in | Diabetes care Vol. 6; no. 4; pp. 374 - 377 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
United States
American Diabetes Association
01.07.1983
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Subjects | |
Online Access | Get full text |
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Summary: | Importance of timing of preprandial subcutaneous insulin administration in the management of diabetes mellitus.
G D Dimitriadis and
J E Gerich
Abstract
Since little is known regarding the appropriate time for preprandial insulin administration, we compared the effects of 30-min
subcutaneous insulin infusions started 60 min, 30 min, and immediately before meal ingestion on postprandial plasma glucose
and insulin profiles in eight subjects with insulin-dependent diabetes mellitus. Of these three regimens, administration of
insulin 60 min before meal ingestion provided plasma glucose and insulin profiles closest to normal and permitted less insulin
to be used. Our results suggest that adjustments in the timing as well as in the amount of insulin administered preprandially
may be used in the management of diabetes and that prolonging the interval between administration of insulin and meal ingestion
may reduce insulin requirements and thus decrease the hyperinsulinemia usually associated with insulin therapy. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0149-5992 1935-5548 |
DOI: | 10.2337/diacare.6.4.374 |