Plasma markers of inflammation and prediction of cardiovascular disease and mortality in African Americans with type 1 diabetes

• Published in: Diabetes research and clinical practice Vol. 114; pp. 117 - 125
• Main Authors: Roy, Monique S, Janal, Malvin N, Crosby, Juan, Donnelly, Robert
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 01.04.2016
• Subjects: Adolescent; Adult; African Americans - statistics & numerical data; Biomarkers; Biomarkers - blood; Cardiovascular disease; Cardiovascular Diseases - blood; Cardiovascular Diseases - diagnosis; Cardiovascular Diseases - epidemiology; Cardiovascular Diseases - mortality; Chemokine CXCL12 - blood; Cholesterol - blood; Cholesterol, LDL - blood; Diabetes; Diabetes Mellitus, Type 1 - complications; Diabetes Mellitus, Type 1 - physiopathology; Endocrinology & Metabolism; Female; Glycated Hemoglobin A - analysis; Humans; Incidence; Inflammation; Inflammation - blood; Inflammation - diagnosis; Inflammation - epidemiology; Inflammation - mortality; Interleukin-10 - blood; Male; Mortality; Mortality - ethnology; Prognosis; Risk Factors; Survival Rate; United States - epidemiology; Young Adult; Biomarkers; Cardiovascular disease; Inflammation; Diabetes; Mortality
• ISSN: 0168-8227; 1872-8227
• DOI: 10.1016/j.diabres.2015.12.014

Highlights • Macroangiopathy and associated morbidity are severe in diabetes. • Inflammation has been reported in association with macroangiopathy in diabetes. • In African Americans with type 1 diabetes, high baseline plasma IP-10 predicts cardiovascular disease and low baseline plasma stromal-derived factor-1 mortality.