Progress of Ginsenoside Rb1 in neurological disorders

Ginseng is frequently used in traditional Chinese medicine to treat neurological disorders. The primary active component of ginseng is ginsenoside, which has been classified into more than 110 types based on their chemical structures. Ginsenoside Rb1 (GsRb1)-a protopanaxadiol saponin and a typical g...

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Published inFrontiers in pharmacology Vol. 15; p. 1280792
Main Authors Ling, Gongxia, Zhang, Min, Chen, Chizhang, Wang, Yan, Gao, Qiqi, Li, Jianshun, Yuan, Hao, Jin, Wenwen, Lin, Wei, Yang, Lingrong
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 2024
Subjects
actions
Ginsenoside Rb1
mechanisms
neurological disorders
pharmacokinetics
Pharmacology
pharmacokinetics
Ginsenoside Rb1
actions
mechanisms
neurological disorders
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Summary:Ginseng is frequently used in traditional Chinese medicine to treat neurological disorders. The primary active component of ginseng is ginsenoside, which has been classified into more than 110 types based on their chemical structures. Ginsenoside Rb1 (GsRb1)-a protopanaxadiol saponin and a typical ginseng component-exhibits anti-inflammatory, anti-oxidant, anti-apoptotic, and anti-autophagy properties in the nervous system. Neurological disorders remain a leading cause of death and disability globally. GsRb1 effectively treats neurological disorders. To contribute novel insights to the understanding and treatment of neurological disorders, we present a comprehensive review of the pharmacokinetics, actions, mechanisms, and research development of GsRb1 in neurological disorders.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
Edited by: Ik-Hyun Cho, Kyung Hee University, Republic of Korea
Yan Gao, Capital Medical University, China
Reviewed by: Guoqi Zhu, Anhui University of Chinese Medicine, China
ISSN:1663-9812
1663-9812
DOI:10.3389/fphar.2024.1280792