Molecular mechanism of PPAR in the regulation of age-related inflammation

Abstract Evidence from many recent studies has linked uncontrolled inflammatory processes to aging and aging-related diseases. Decreased a nuclear receptor subfamily of transcription factors, peroxisome proliferator-activated receptors (PPARs) activity is closely associated with increased levels of...

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Published in	Ageing research reviews Vol. 7; no. 2; pp. 126 - 136
Main Authors	Chung, Jae Heun, Seo, Arnold Y, Chung, Sang Woon, Kim, Mi Kyung, Leeuwenburgh, Christiaan, Yu, Byung Pal, Chung, Hae Young
Format	Journal Article
Language	English
Published	England 01.04.2008
Subjects	Aging - drug effects Aging - physiology Alzheimer Disease - drug therapy Alzheimer Disease - metabolism Alzheimer Disease - physiopathology Animals Humans Inflammation - metabolism Inflammation - physiopathology Internal Medicine Neoplasms - drug therapy Neoplasms - etiology Neoplasms - physiopathology Neurology NF-kappa B - metabolism PPAR alpha - agonists PPAR alpha - physiology PPAR gamma - agonists PPAR gamma - physiology Vascular Diseases - drug therapy Vascular Diseases - metabolism Vascular Diseases - physiopathology Aging Inflammation PPARs Inflammatory diseases
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Abstract	Abstract Evidence from many recent studies has linked uncontrolled inflammatory processes to aging and aging-related diseases. Decreased a nuclear receptor subfamily of transcription factors, peroxisome proliferator-activated receptors (PPARs) activity is closely associated with increased levels of inflammatory mediators during the aging process. The anti-inflammatory action of PPARs is substantiated by both in vitro and in vivo studies that signify the importance of PPARs as major players in the pathogenesis of many inflammatory diseases. In this review, we highlight the molecular mechanisms and roles of PPARα, γ in regulation of age-related inflammation. By understanding these current findings of PPARs, we open up the possibility of developing new therapeutic agents that modulate these nuclear receptors to control various inflammatory diseases such as atherosclerosis, vascular diseases, Alzheimer's disease, and cancer.
AbstractList	Abstract Evidence from many recent studies has linked uncontrolled inflammatory processes to aging and aging-related diseases. Decreased a nuclear receptor subfamily of transcription factors, peroxisome proliferator-activated receptors (PPARs) activity is closely associated with increased levels of inflammatory mediators during the aging process. The anti-inflammatory action of PPARs is substantiated by both in vitro and in vivo studies that signify the importance of PPARs as major players in the pathogenesis of many inflammatory diseases. In this review, we highlight the molecular mechanisms and roles of PPARα, γ in regulation of age-related inflammation. By understanding these current findings of PPARs, we open up the possibility of developing new therapeutic agents that modulate these nuclear receptors to control various inflammatory diseases such as atherosclerosis, vascular diseases, Alzheimer's disease, and cancer. Evidence from many recent studies has linked uncontrolled inflammatory processes to aging and aging-related diseases. Decreased a nuclear receptor subfamily of transcription factors, peroxisome proliferator-activated receptors (PPARs) activity is closely associated with increased levels of inflammatory mediators during the aging process. The anti-inflammatory action of PPARs is substantiated by both in vitro and in vivo studies that signify the importance of PPARs as major players in the pathogenesis of many inflammatory diseases. In this review, we highlight the molecular mechanisms and roles of PPARalpha, gamma in regulation of age-related inflammation. By understanding these current findings of PPARs, we open up the possibility of developing new therapeutic agents that modulate these nuclear receptors to control various inflammatory diseases such as atherosclerosis, vascular diseases, Alzheimer's disease, and cancer.
Author	Leeuwenburgh, Christiaan Chung, Jae Heun Yu, Byung Pal Kim, Mi Kyung Seo, Arnold Y Chung, Hae Young Chung, Sang Woon
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Snippet	Abstract Evidence from many recent studies has linked uncontrolled inflammatory processes to aging and aging-related diseases. Decreased a nuclear receptor... Evidence from many recent studies has linked uncontrolled inflammatory processes to aging and aging-related diseases. Decreased a nuclear receptor subfamily of...
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SubjectTerms	Aging - drug effects Aging - physiology Alzheimer Disease - drug therapy Alzheimer Disease - metabolism Alzheimer Disease - physiopathology Animals Humans Inflammation - metabolism Inflammation - physiopathology Internal Medicine Neoplasms - drug therapy Neoplasms - etiology Neoplasms - physiopathology Neurology NF-kappa B - metabolism PPAR alpha - agonists PPAR alpha - physiology PPAR gamma - agonists PPAR gamma - physiology Vascular Diseases - drug therapy Vascular Diseases - metabolism Vascular Diseases - physiopathology
Title	Molecular mechanism of PPAR in the regulation of age-related inflammation
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