Molecular mechanism of PPAR in the regulation of age-related inflammation

• Published in: Ageing research reviews Vol. 7; no. 2; pp. 126 - 136
• Main Authors: Chung, Jae Heun, Seo, Arnold Y, Chung, Sang Woon, Kim, Mi Kyung, Leeuwenburgh, Christiaan, Yu, Byung Pal, Chung, Hae Young
• Format: Journal Article
• Language: English
• Published: England 01.04.2008
• Subjects: Aging - drug effects; Aging - physiology; Alzheimer Disease - drug therapy; Alzheimer Disease - metabolism; Alzheimer Disease - physiopathology; Animals; Humans; Inflammation - metabolism; Inflammation - physiopathology; Internal Medicine; Neoplasms - drug therapy; Neoplasms - etiology; Neoplasms - physiopathology; Neurology; NF-kappa B - metabolism; PPAR alpha - agonists; PPAR alpha - physiology; PPAR gamma - agonists; PPAR gamma - physiology; Vascular Diseases - drug therapy; Vascular Diseases - metabolism; Vascular Diseases - physiopathology; Aging; Inflammation; PPARs; Inflammatory diseases
• ISSN: 1568-1637
• DOI: 10.1016/j.arr.2008.01.001

Abstract Evidence from many recent studies has linked uncontrolled inflammatory processes to aging and aging-related diseases. Decreased a nuclear receptor subfamily of transcription factors, peroxisome proliferator-activated receptors (PPARs) activity is closely associated with increased levels of inflammatory mediators during the aging process. The anti-inflammatory action of PPARs is substantiated by both in vitro and in vivo studies that signify the importance of PPARs as major players in the pathogenesis of many inflammatory diseases. In this review, we highlight the molecular mechanisms and roles of PPARα, γ in regulation of age-related inflammation. By understanding these current findings of PPARs, we open up the possibility of developing new therapeutic agents that modulate these nuclear receptors to control various inflammatory diseases such as atherosclerosis, vascular diseases, Alzheimer's disease, and cancer.