Comparison of imaging markers of nerve ultrasound and MR-neurography in a longitudinal course in chronic inflammatory demyelinating polyneuropathy

• Published in: Therapeutic advances in neurological disorders Vol. 18; p. 17562864251342336
• Main Authors: Lüling, Benjamin, Preisner, Fabian, Motte, Jeremias, Fisse, Anna Lena, Grüter, Thomas, Klimas, Rafael, Schäfer, Emelie, Altenborg, Annika, Colak, Devrim, Philipps, Jörg, Godel, Tim, Schwarz, Daniel, Heiland, Sabine, Yoon, Min-Suk, Gold, Ralf, Bendszus, Martin, Kronlage, Moritz, Pitarokoili, Kalliopi
• Format: Journal Article
• Language: English
• Published: England SAGE Publications 01.01.2025; SAGE Publishing
• Subjects: Original Research; high resolution ultrasound; chronic inflammatory demyelinating polyneuropathy; magnetic resonance neurography; inflammatory neuropathy; peripheral neuropathy; nerve conduction studies
• ISSN: 1756-2864; 1756-2856; 1756-2864
• DOI: 10.1177/17562864251342336

The novel criteria for the diagnosis of chronic inflammatory demyelinating polyneuropathy (CIDP) have established imaging with nerve ultrasound (NUS) and magnetic resonance neurography (MRN) as complementary methods for CIDP diagnosis. Our goal was to investigate the role of MRN and NUS for CIDP monitoring. We longitudinally examined 12 CIDP patients from 2016 to 2022 using NUS, MRN, nerve conduction studies (NCS), and clinical parameters (inflammatory neuropathy cause and treatment (INCAT)/overall disability sum score (ODSS)). NUS evaluated the cross-sectional area (CSA) of the median, ulnar, radial, tibial, fibular, and sural nerve as well as the intranerve CSA variability (INV ) of the tibial, fibular, ulnar, and median nerve, whereas MRN evaluated T2-weighted sequences of the fibular and tibial nerve at the popliteal fossa. Five patients showed clinical improvement/stability with corresponding improved or stable NCS/NUS parameters (number of nerves with increased CSA and INV ). Seven deteriorating patients showed deteriorating NCS and either increasing or decreasing NUS markers possibly indicating inflammatory activity or degenerative CSA reduction. The difference ΔINCAT/ODSS correlated positively with NUS ΔINV (  = 0.007,  = 0.731,  = 12) and with NUS ΔCSA of the tibial nerve (  = 0.0005,  = 0.865,  = 12). Further, NUS-CSA of the tibial nerve in the popliteal fossa in 2016 correlated inversely with the difference of the INCAT/ODSS score (ΔINCAT/ODSS ;  = -0.653;  = 0.033;  = 11). Finally, the Bland-Altman analyses for the tibial and fibular nerve showed a bias of -1.903 and 2.195 mm (bias = NUS-CSA - MRN-CSA) accordingly revealing a difference between MRN and NUS measurements for deeper nerves. CSA and INV of the tibial and fibular nerve can be used for monitoring in CIDP, and increased CSA of the tibial nerve is a good prognostic marker. MRN is more reliable for evaluating inflammation in proximal leg nerve segments.