Molecular Mechanisms for Regulation of Neutrophil Apoptosis under Normal and Pathological Conditions

Neutrophils are one of the main cells of innate immunity that perform a key effector and regulatory function in the development of the human inflammatory response. Apoptotic forms of neutrophils are important for regulating the intensity of inflammation and restoring tissue homeostasis. This review...

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Bibliographic Details
Published inJournal of evolutionary biochemistry and physiology Vol. 57; no. 3; pp. 429 - 450
Main Authors Noseykina, E. M., Schepetkin, I. A., Atochin, D. N.
Format Journal Article
LanguageEnglish
Published Moscow Pleiades Publishing 2021
Subjects
Animal Physiology
Biochemistry
Biomedical and Life Sciences
Evolutionary Biology
Life Sciences
Reviews
stress
innate immunity
inflammation
apoptosis
cytokines
cell life span
neutrophils
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Summary:Neutrophils are one of the main cells of innate immunity that perform a key effector and regulatory function in the development of the human inflammatory response. Apoptotic forms of neutrophils are important for regulating the intensity of inflammation and restoring tissue homeostasis. This review summarizes current data on the molecular mechanisms of modulation of neutrophil apoptosis by the main regulatory factors of the inflammatory response—cytokines, integrins, and structural components of bacteria. Disturbances in neutrophil apoptosis under stress are also considered, molecular markers of changes in neutrophil lifespan associated with various diseases and pathological conditions are presented, and data on pharmacological agents for modulating apoptosis as potential therapeutics are also discussed.
Bibliography:ObjectType-Article-1
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ISSN:0022-0930
1608-3202
DOI:10.1134/S0022093021030017