Advances in targeted therapy and biomarker research in thyroid cancer

• Published in: Frontiers in endocrinology (Lausanne) Vol. 15; p. 1372553
• Main Authors: Guo, Mei, Sun, Yuqi, Wei, Yuyao, Xu, Jianxin, Zhang, Chun
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 04.03.2024
• Subjects: biomarker research; Biomarkers, Tumor - genetics; Biomarkers, Tumor - metabolism; clinical application; disease treatment; Endocrinology; Humans; Precision Medicine; Prognosis; Quality of Life; targeted therapy; thyroid cancer; Thyroid Neoplasms - drug therapy; Thyroid Neoplasms - genetics; disease treatment; targeted therapy; clinical application; thyroid cancer; biomarker research
• ISSN: 1664-2392; 1664-2392
• DOI: 10.3389/fendo.2024.1372553

Driven by the intricacy of the illness and the need for individualized treatments, targeted therapy and biomarker research in thyroid cancer represent an important frontier in oncology. The variety of genetic changes associated with thyroid cancer demand more investigation to elucidate molecular details. This research is clinically significant since it can be used to develop customized treatment plans. A more focused approach is provided by targeted therapies, which target certain molecular targets such as mutant BRAF or RET proteins. This strategy minimizes collateral harm to healthy tissues and may also reduce adverse effects. Simultaneously, patient categorization based on molecular profiles is made possible by biomarker exploration, which allows for customized therapy regimens and maximizes therapeutic results. The benefits of targeted therapy and biomarker research go beyond their immediate clinical impact to encompass the whole cancer landscape. Comprehending the genetic underpinnings of thyroid cancer facilitates the creation of novel treatments that specifically target aberrant molecules. This advances the treatment of thyroid cancer and advances precision medicine, paving the way for the treatment of other cancers. Taken simply, more study on thyroid cancer is promising for better patient care. The concepts discovered during this investigation have the potential to completely transform the way that care is provided, bringing in a new era of personalized, precision medicine. This paradigm shift could improve the prognosis and quality of life for individuals with thyroid cancer and act as an inspiration for advances in other cancer types.