The expression of Toll-like receptors in patients with acute myeloid leukemia treated with induction chemotherapy

Highlights • The expression of TLRs in patients with AML was evaluated. • Using RQ-PCR, the mRNA expression of genes TLR2, TLR4 and TLR9 was measured. • TLRs could be a new prognostic factor for response rate in patients with AML.

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Bibliographic Details
Published inLeukemia research Vol. 39; no. 3; pp. 318 - 322
Main Authors Rybka, Justyna, Butrym, Aleksandra, Wróbel, Tomasz, Jaźwiec, Bożena, Stefanko, Ewa, Dobrzyńska, Olga, Poręba, Rafał, Kuliczkowski, Kazimierz
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.03.2015
Subjects
Acute myeloid leukemia
Adolescent
Adult
Aged
Aged, 80 and over
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Biomarkers, Tumor - genetics
Case-Control Studies
Complete remission
Female
Follow-Up Studies
Hematology, Oncology and Palliative Medicine
Humans
Induction Chemotherapy
Induction therapy
Leukemia, Myeloid, Acute - drug therapy
Leukemia, Myeloid, Acute - genetics
Leukemia, Myeloid, Acute - mortality
Male
Middle Aged
Prognosis
Real-Time Polymerase Chain Reaction
Reverse Transcriptase Polymerase Chain Reaction
RNA, Messenger - genetics
Survival Rate
Toll like receptors
Toll-Like Receptor 2 - genetics
Toll-Like Receptor 4 - genetics
Toll-Like Receptor 9 - genetics
Young Adult
Complete remission
Acute myeloid leukemia
Induction therapy
Toll like receptors
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Summary:Highlights • The expression of TLRs in patients with AML was evaluated. • Using RQ-PCR, the mRNA expression of genes TLR2, TLR4 and TLR9 was measured. • TLRs could be a new prognostic factor for response rate in patients with AML.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0145-2126
1873-5835
DOI:10.1016/j.leukres.2015.01.002