Immune cells in the healing skin wound: Influential players at each stage of repair

Immune cells are involved in virtually every aspect of the wound repair process, from the initial stages where they participate in hemostasis and work to prevent infection to later stages where they drive scar formation. Traditional views maintain that a strong immune response is advantageous for wo...

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Bibliographic Details
Published inPharmacological research Vol. 58; no. 2; pp. 112 - 116
Main Author Wilgus, Traci A.
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Ltd 01.08.2008
Subjects
Animals
Cell Proliferation
Cicatrix - physiopathology
Humans
Immune system
Immune System - physiology
Inflammation
Mast Cells - physiology
Scar
Wound healing
Wound Healing - physiology
Inflammation
Wound healing
Scar
Immune system
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Summary:Immune cells are involved in virtually every aspect of the wound repair process, from the initial stages where they participate in hemostasis and work to prevent infection to later stages where they drive scar formation. Traditional views maintain that a strong immune response is advantageous for wound healing, but newer data have questioned the validity of this idea. As a result, opinions about how cells of the immune system contribute to the repair process have changed considerably over the past few years. Here, current studies investigating how different immune cell lineages function in the various stages of repair will be reviewed and their impact on the wound healing field will be discussed.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1043-6618
1096-1186
DOI:10.1016/j.phrs.2008.07.009