Cytochrome P450 and its role in veterinary drug interactions

Cytochrome P450 (CYP) enzymes are common sites of drug interactions in human beings. Drugs may act as inhibitors or inducers of CYPs, leading to altered clearance of a second drug. Clinically relevant drug interactions involving various CYP isoforms in people, including CYP1A2, CYP2C9, CYP2D6, and C...

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Bibliographic Details
Published inThe Veterinary clinics of North America. Small animal practice Vol. 36; no. 5; p. 975
Main Author Trepanier, Lauren A
Format Journal Article
LanguageEnglish
Published United States 01.09.2006
Subjects
Animals
Cats - metabolism
Cytochrome P-450 Enzyme System - metabolism
Dogs - metabolism
Drug Interactions
Humans
Veterinary Drugs - metabolism
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Summary:Cytochrome P450 (CYP) enzymes are common sites of drug interactions in human beings. Drugs may act as inhibitors or inducers of CYPs, leading to altered clearance of a second drug. Clinically relevant drug interactions involving various CYP isoforms in people, including CYP1A2, CYP2C9, CYP2D6, and CYP3A4, have been well documented. Analogous interactions are beginning to be characterized in dogs, for which canine CYPs share many of the same substrate ranges as in human beings.
ISSN:0195-5616
DOI:10.1016/j.cvsm.2006.05.003