Cell Adhesion: A FERM Grasp of the Tail Sorts Out Integrins

As well as modulating integrin activation, a conserved NPxY motif in integrin cytoplasmic tails that binds the FERM-domain-containing proteins kindlin and sorting nexin 17 plays pivotal roles in integrin recycling and degradation.

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Bibliographic Details
Published inCurrent biology Vol. 22; no. 17; pp. R692 - R694
Main Authors Brahme, Nina N., Calderwood, David A.
Format Journal Article
LanguageEnglish
Published England Elsevier Inc 11.09.2012
Subjects
Animals
cell adhesion
Cytoskeletal Proteins - physiology
Integrin alpha5beta1 - physiology
integrins
Muscle Proteins - physiology
sorting
Talin - physiology
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Summary:As well as modulating integrin activation, a conserved NPxY motif in integrin cytoplasmic tails that binds the FERM-domain-containing proteins kindlin and sorting nexin 17 plays pivotal roles in integrin recycling and degradation.
Bibliography:http://dx.doi.org/10.1016/j.cub.2012.07.049
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ISSN:0960-9822
1879-0445
DOI:10.1016/j.cub.2012.07.049