Ambuic acid, a highly functionalized cyclohexenone with antifungal activity from Pestalotiopsis spp. and Monochaetia sp

• Published in: Phytochemistry (Oxford) Vol. 56; no. 5; pp. 463 - 468
• Main Authors: Li, J.Y., Harper, James K., Grant, David M., Tombe, Bob Oka, Bashyal, Bharat, Hess, W.M., Strobel, Gary A.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ltd 01.03.2001; Elsevier
• Subjects: Ambuic acid; Antifungal Agents - chemistry; Antifungal Agents - isolation & purification; Antifungal Agents - pharmacology; Antimycotic; Biological and medical sciences; Chemical control; Chromatography, High Pressure Liquid; Control; Cyclohexanones - chemistry; Cyclohexanones - isolation & purification; Cyclohexanones - pharmacology; Cyclohexenone; Endophytic fungi; Fundamental and applied biological sciences. Psychology; Fungal plant pathogens; Magnetic Resonance Spectroscopy; Mitosporic Fungi - chemistry; Monochaetia; Pestalotiopsis; Phytopathology. Animal pests. Plant and forest protection; Rainforest; Cyclohexenone; Antimycotic; Endophytic fungi; Rainforest; Ambuic acid; Cyclohexane derivatives; Bioassay; Molecular structure; Pesticides; Pestalotiopsis; Organic acids; Biological activity; Fungicide; Fungi; Endophyte; Isolation; Fungi Imperfecti; Thallophyta
• ISSN: 0031-9422; 1873-3700
• DOI: 10.1016/S0031-9422(00)00408-8

Ambuic acid, a highly functionalized cyclohexenone, was isolated and characterized from Pestalotiopsis spp. and Monochaetia sp. these being biologically related endophytic fungi associated with many tropical plant species. This compound was found in representative isolates of these fungal species obtained from rainforest plants located on several continents. The relevance of ambuic acid to the biology of the association of these fungi to their host plants is also discussed.