Early detection of myocardial involvement by non-contrast T1ρ mapping of cardiac magnetic resonance in type 2 diabetes mellitus

• Published in: Frontiers in endocrinology (Lausanne) Vol. 15; p. 1335899
• Main Authors: Shu, Hongmin, Xu, Huimin, Pan, Zixiang, Liu, Yan, Deng, Wei, Zhao, Ren, Sun, Yan, Wang, Zhen, Yang, Jinxiu, Gao, Hui, Yao, Kaixuan, Zheng, Jie, Yu, Yongqiang, Li, Xiaohu
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 05.03.2024
• Subjects: Cardiomyopathies - pathology; diabetes mellitus; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - diagnostic imaging; Diabetes Mellitus, Type 2 - pathology; Endocrinology; extracellular volume fraction; Fibrosis; Heart; Humans; Magnetic Resonance Spectroscopy; myocardial diffuse fibrosis; Myocardium - pathology; spin-lock; T1ρ mapping; diabetes mellitus; extracellular volume fraction; T1ρ mapping; myocardial diffuse fibrosis; spin-lock
• ISSN: 1664-2392; 1664-2392
• DOI: 10.3389/fendo.2024.1335899

This study aims to determine the effectiveness of T1ρ in detecting myocardial fibrosis in type 2 diabetes mellitus (T2DM) patients by comparing with native T1 and extracellular volume (ECV) fraction. T2DM patients (n = 35) and healthy controls (n = 30) underwent cardiac magnetic resonance. ECV, T1ρ, native T1, and global longitudinal strain (GLS) values were assessed. Diagnostic performance was analyzed using receiver operating curves. The global ECV and T1ρ of T2DM group (ECV = 32.1 ± 3.2%, T1ρ = 51.6 ± 3.8 msec) were significantly higher than those of controls (ECV = 26.2 ± 1.6%, T1ρ = 46.8 ± 2.0 msec) (all P < 0.001), whether there was no significant difference in native T1 between T2DM and controls (P = 0.264). The GLS decreased significantly in T2DM patients compared with controls (-16.5 ± 2.4% vs. -18.3 ± 2.6%, P = 0.015). The T1ρ and native T1 were associated with ECV (Pearson's r = 0.50 and 0.25, respectively, both P < 0.001); the native T1, T1ρ, and ECV were associated with hemoglobin A1c (Pearson's r = 0.41, 0.52, and 0.61, respectively, all P < 0.05); and the ECV was associated with diabetes duration (Pearson's r = 0.41, P = 0.016). The AUC of ECV, T1ρ, GLS, and native T1 were 0.869, 0.810, 0.659, and 0.524, respectively. In T2DM patients, T1ρ may be a new non-contrast cardiac magnetic resonance technique for identifying myocardial diffuse fibrosis, and T1ρ may be more sensitive than native T1 in the detection of myocardial diffuse fibrosis.