Management of Clostridioides difficile colitis: insights for the gastroenterologist

Clostridioides difficile infection (CDI) is a common cause of diarrhea in both inpatient and outpatient settings. The last few years have seen major changes in the treatment spectrum of CDI, most notably, recommendations against using metronidazole for initial CDI, the addition of fidaxomicin and be...

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Bibliographic Details
Published inTherapeutic Advances in Gastroenterology Vol. 12; p. 1756284819847651
Main Authors Saha, Srishti, Khanna, Sahil
Format Book Review Journal Article
LanguageEnglish
Published London, England SAGE Publications 2019
Sage Publications Ltd
Subjects
Gastroenterology
Infectious diseases
Review
Clostridioides difficile
C. difficile diarrhea
fecal microbiota transplantation
Clostridium difficile
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Summary:Clostridioides difficile infection (CDI) is a common cause of diarrhea in both inpatient and outpatient settings. The last few years have seen major changes in the treatment spectrum of CDI, most notably, recommendations against using metronidazole for initial CDI, the addition of fidaxomicin and bezlotoxumab, and emergence of microbial replacement therapies. Several other therapies are undergoing clinical trials. This narrative review focuses on the treatment of CDI with a summary of literature on the newer modalities and the treatment guidelines issued by Infectious Diseases Society of America and European Society of Clinical Microbiology and Infectious Diseases.
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ISSN:1756-2848
1756-283X
1756-2848
DOI:10.1177/1756284819847651