Epigenetic regulation of macrophage activation in chronic obstructive pulmonary disease

Macrophages in the innate immune system play a vital role in various lung diseases such as asthma, chronic obstructive pulmonary disease (COPD), acute lung injury and pulmonary fibrosis. Macrophages involved in the process of immunity need to go through a process of activation, including changes in...

Full description

Saved in:
Bibliographic Details
Published inFrontiers in immunology Vol. 15; p. 1445372
Main Authors Zhang, Feng, Cui, Yachao, Zhang, Tiejun, Yin, Wenguang
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 14.08.2024
Subjects
Animals
COPD
DNA Methylation
Epigenesis, Genetic
epigenetic regulation
histone modifications
Humans
Immunology
macrophage
Macrophage Activation - genetics
Macrophage Activation - immunology
Macrophages - immunology
Macrophages - metabolism
Pulmonary Disease, Chronic Obstructive - genetics
Pulmonary Disease, Chronic Obstructive - immunology
DNA methylation
macrophage
histone modifications
epigenetic regulation
COPD
Online AccessGet full text

Cover

More Information
Summary:Macrophages in the innate immune system play a vital role in various lung diseases such as asthma, chronic obstructive pulmonary disease (COPD), acute lung injury and pulmonary fibrosis. Macrophages involved in the process of immunity need to go through a process of activation, including changes in gene expression and cell metabolism. Epigenetic modifications are key factors of macrophage activation including DNA methylation, histone modification and non-coding RNA regulation. Understanding the role and mechanisms of epigenetic regulation of macrophage activation can provide insights into the function of macrophages in lung diseases and help identification of potential therapeutic targets. This review summarizes the latest progress in the epigenetic changes and regulation of macrophages in their development process and in normal physiological states, and the epigenetic regulation of macrophages in COPD as well as the influence of macrophage activation on COPD development.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
Reviewed by: Loka Raghu Kumar Penke, Ionis Pharmaceuticals, Inc., United States
Mallar Bhattacharya, University of California, San Francisco, United States
Edited by: Christoph Beisswenger, Saarland University, Germany
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2024.1445372