Dietary α-linolenic acid and immunocompetence in humans
We examined the effect of dietary α-linolenic acid (ALA) on the indices of immunocompetence in 10 healthy free-living men (age 21–37 y) who consumed all meals at the Western Human Nutrition Research Center for 126 d. There was a stabilization period of 14 d at the start when all 10 subjects consumed...
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Published in | The American journal of clinical nutrition Vol. 53; no. 1; pp. 40 - 46 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Bethesda, MD
Elsevier Inc
01.01.1991
American Society for Clinical Nutrition |
Subjects | |
Online Access | Get full text |
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Summary: | We examined the effect of dietary α-linolenic acid (ALA) on the indices of immunocompetence in 10 healthy free-living men (age 21–37 y) who consumed all meals at the Western Human Nutrition Research Center for 126 d. There was a stabilization period of 14 d at the start when all 10 subjects consumed basal diet (BD) and there were two intervention periods of 56 d each. Five of the subjects consumed the basal diet and the other five consumed flax-seed-oil diet (FD) during each intervention period. Feeding of FD suppressed the proliferation of peripheral blood mononuclear cells when they were cultured with phytohemagglutinin-P (P = 0.041) and concanavalin A (P = 0.054) and the delayed hypersensitivity response to seven recall antigens (NS). Concentrations of immunoglobulins in serum, C3, C4, salivary IgA, the numbers of helper cells, suppressor cells, and total T and B cells in the peripheral blood were not affected by the diets. |
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Bibliography: | S20 S30 9111607 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 |
ISSN: | 0002-9165 1938-3207 |
DOI: | 10.1093/ajcn/53.1.40 |