The effect of layer thickness ratio on the drug release behavior of alternating layered composite prepared by layer-multiplying co-extrusion

• Published in: Frontiers in bioengineering and biotechnology Vol. 11; p. 1217938
• Main Authors: Zheng, Huiyu, Zhang, Cong, Liu, Guiting, Chen, Rong, Guo, Shaoyun
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 23.06.2023
• Subjects: Bioengineering and Biotechnology; drug release; extrusion; interface; layered structures; scaffold; drug release; layered structures; interface; scaffold; extrusion
• ISSN: 2296-4185; 2296-4185
• DOI: 10.3389/fbioe.2023.1217938

Multi-layered drug delivery (MLDD) system has promising potential to achieve controlled release. However, existing technologies face difficulties in regulating the number of layers and layer-thickness ratio. In our previous works, layer-multiplying co-extrusion (LMCE) technology was applied to regulate the number of layers. Herein, we utilized layer-multiplying co-extrusion technology to modulate the layer-thickness ratio to expand the application of LMCE technology. Four-layered poly (ε-caprolactone)-metoprolol tartrate/poly (ε-caprolactone)-polyethylene oxide (PCL-MPT/PEO) composites were continuously prepared by LMCE technology, and the layer-thickness ratios for PCL-PEO layer and PCL-MPT layer were set to be 1:1, 2:1, and 3:1 just by controlling the screw conveying speed. The release test indicated that the rate of MPT release increased with decreasing the thickness of the PCL-MPT layer. Additionally, when PCL-MPT/PEO composite was sealed by epoxy resin to eliminate the edge effect, sustained release of MPT was achieved. The compression test confirmed the potential of PCL-MPT/PEO composites as bone scaffolds.