Evolution of a defective virus from a cellular defense mechanism

Adeno-associated virus is a defective DNA virus, requiring the presence of a helper virus in order to replicate. In this paper we consider its origin in light of several observations, most notably the following: its own replication inhibits that of the helper virus; its DNA structure resembles that...

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Published inJournal of theoretical biology Vol. 118; no. 4; pp. 395 - 404
Main Authors Fisher, Ronald E., Mayor, Heather D.
Format Journal Article
LanguageEnglish
Published Sidcup Elsevier Ltd 21.02.1986
Elsevier
Subjects
adeno-associated virus
Biological and medical sciences
Biological Evolution
Dependovirus - genetics
Dependovirus - physiology
DNA Replication
DNA Transposable Elements
DNA, Single-Stranded
DNA, Viral
Fundamental and applied biological sciences. Psychology
Genetics
Microbiology
Models, Genetic
Virology
Virus Replication
Virus
Parvoviridae
DNA
Biological evolution
Transposon
Defense mechanism
Dependovirus
Defectivity
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Summary:Adeno-associated virus is a defective DNA virus, requiring the presence of a helper virus in order to replicate. In this paper we consider its origin in light of several observations, most notably the following: its own replication inhibits that of the helper virus; its DNA structure resembles that of transposable (moveable) elements; and extrachromosomal circles of DNA, about the size of adeno-associated virus DNA, have been found recently in eukaryotic cells. We have arrived at a hypothesis consisting of two main ideas: (1) that cells may use transposable DNA as a mechanism of defense against viral attack, and (2) that adeno-associated virus may have evolved directly from this cellular defense mechanism.
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ISSN:0022-5193
1095-8541
DOI:10.1016/S0022-5193(86)80161-8