Acute intestinal graft-versus-host disease in a syngeneic bone marrow transplant recipient

We report a case of intestinal graft-versus-host disease (GVHD) in a syngeneic bone marrow transplant patient. Several days after receiving a bone marrow transplant from his identical twin for treatment of non-Hodgkin's lymphoma, a 47-year-old man developed a skin rash and diarrhea. A colonic b...

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Bibliographic Details
Published inTransplantation Vol. 66; no. 9; p. 1251
Main Authors Spaner, D, Lowsky, R, Fyles, G, Lipton, J H, Banerjee, D, Ng, C M, Wade, J A, Messner, H A
Format Journal Article
LanguageEnglish
Published United States 15.11.1998
Subjects
Acute Disease
Bone Marrow Transplantation - immunology
Cyclosporine - adverse effects
Graft vs Host Disease - chemically induced
Humans
Immunosuppressive Agents - adverse effects
Intestinal Diseases - immunology
Lymphoma, Non-Hodgkin - therapy
Male
Middle Aged
Transplantation, Isogeneic
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Summary:We report a case of intestinal graft-versus-host disease (GVHD) in a syngeneic bone marrow transplant patient. Several days after receiving a bone marrow transplant from his identical twin for treatment of non-Hodgkin's lymphoma, a 47-year-old man developed a skin rash and diarrhea. A colonic biopsy on day +15 revealed characteristic changes of acute intestinal GVHD. Molecular studies (microsatellite DNA and HLA sequence-specific primer polymerase chain reaction analyses) confirmed the genotypic identity of donor and host and the improbability of transfusion-associated GVHD. This case illustrates that pathological evidence of GVHD does not absolutely require the presence of genetic differences between host and donor and questions existing concepts about the nature of cyclosporine-induced GVHD.
ISSN:0041-1337
DOI:10.1097/00007890-199811150-00022