Angiotensin-converting enzyme overexpression in myelocytes enhances the immune response

• Published in: Biological chemistry Vol. 395; no. 10; pp. 1173 - 1178
• Main Authors: Bernstein, Kenneth E., Gonzalez-Villalobos, Romer A., Giani, Jorge F., Shah, Kandarp, Bernstein, Ellen, Janjulia, Tea, Koronyo, Yosef, Shi, Peng D., Koronyo-Hamaoui, Maya, Fuchs, Sebastien, Shen, Xiao Z.
• Format: Journal Article
• Language: English
• Published: Germany De Gruyter 01.10.2014
• Subjects: ACE 10/10; Alzheimer disease; Animals; Granulocyte Precursor Cells - enzymology; Granulocyte Precursor Cells - immunology; Immunity, Cellular - genetics; macrophages; Mice; Mice, Knockout; monocytes; peptidase; Peptidyl-Dipeptidase A - biosynthesis; Peptidyl-Dipeptidase A - genetics
• ISSN: 1431-6730; 1437-4315
• DOI: 10.1515/hsz-2013-0295

Angiotensin-converting enzyme (ACE) plays an important role in blood pressure control. ACE also has effects on renal function, reproduction, hematopoiesis, and several aspects of the immune response. ACE 10/10 mice overexpress ACE in monocytic cells; macrophages from ACE 10/10 mice demonstrate increased polarization toward a proinflammatory phenotype. As a result, ACE 10/10 mice have a highly effective immune response following challenge with melanoma, bacterial infection, or Alzheimer disease. As shown in ACE 10/10 mice, enhanced monocytic function greatly contributes to the ability of the immune response to defend against a wide variety of antigenic and non-antigenic challenges.