Pentylenetetrazol kindling decreases N-methyl- d-aspartate and kainate but increases gamma-aminobutyric acid-A receptor binding in discrete rat brain areas
Pentylenetetrazol is a convulsive drug acting on gamma-aminobutyric acid-A (GABA A) gated-chloride receptors. In this study we used a subconvulsive dose (30 mg/kg) of pentylenetetrazol to induce a fully kindled state in rats. Glutamate receptors were evaluated using [ 3H]-[1(2-thienylcyclohexyl)]-pi...
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Published in | Neuroscience letters Vol. 239; no. 1; pp. 9 - 12 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
Shannon
Elsevier Ireland Ltd
12.12.1997
Elsevier |
Subjects | |
Online Access | Get full text |
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Summary: | Pentylenetetrazol is a convulsive drug acting on gamma-aminobutyric acid-A (GABA
A) gated-chloride receptors. In this study we used a subconvulsive dose (30 mg/kg) of pentylenetetrazol to induce a fully kindled state in rats. Glutamate receptors were evaluated using [
3H]-[1(2-thienylcyclohexyl)]-piperidin (TCP) and [
3H]kainate receptor autoradiography and [
3H]muscimol autoradiography was used to study GABA
A receptors. In fully kindled rats decreased
N-methyl-
d-aspartate receptor binding was found in parietal cortex, area CA2 of hippocampus and piriform cortex. Decreased kainate receptor binding was observed in all areas of the hippocampus, the medial amygdala and in the piriform cortex in the kindled rats. In contrast, GABA
A receptor binding increased in the dentate gyrus. It is concluded that modulatory neuronal plasticity events are induced in fully pentylenetetrazol kindled rats, which appears to lead to decreased glutamatergic excitation and increased GABAergic inhibition in brain regions implicated in the development of seizure activity. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 |
ISSN: | 0304-3940 1872-7972 |
DOI: | 10.1016/S0304-3940(97)00880-X |