Effect of L364.718 during suckling on the sensitivity to the hypophagic effect of cholecystokinin in adult rats

• Published in: Progress in neuro-psychopharmacology & biological psychiatry Vol. 21; no. 1; pp. 183 - 192
• Main Authors: Voits, Mechthild, Rodel, Stefan, Förster, Susan, Plagemann, Andreas, Fink, Heidrun
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Inc 1997; Elsevier
• Subjects: Animals; Benzodiazepinones - pharmacology; Biological and medical sciences; Body Weight - drug effects; CCK-8S; CCK-A receptor; cholecystokinin; Devazepide; Eating - drug effects; Feeding. Feeding behavior; Female; food intake; Fundamental and applied biological sciences. Psychology; Hormone Antagonists - pharmacology; L-364.718; Male; postnatal development; rat; Rats; Rats, Wistar; Receptors, Cholecystokinin - drug effects; Sex Factors; Sincalide - pharmacology; Vertebrates: anatomy and physiology, studies on body, several organs or systems; rat; CCK-A receptor; cholecystokinin; CCK-8S; L-364.718; sulphated cholecystokinin-octapeptide; food intake; postnatal development; Feeding behavior; Rat; Body weight; Peptide hormone; Rodentia; Suckling animal; CCK A receptor; Neuropeptide; Postnatal development; Vertebrata; Gastrointestinal hormone; Mammalia; Food intake; Antagonist; Cholecystokinin
• ISSN: 0278-5846; 1878-4216
• DOI: 10.1016/S0278-5846(96)00166-2

1. 1. In the present study it was investigated whether drugs acting at the cholecystokinin (CCK)-A receptor given to rat pups may result in long-lasting changes in body weight or regulation of food intake controlled by CCK. 2. 2. From day 3 to day 10 of life, male and female Wistar rat pups were treated with the CCK-A receptor antagonist L-364.718 and the CCK-A+B agonist CCK-8S. 3. 3. In adult rats, treated with L364.718 during suckling, the sensitivity to the acute hypophagic action of CCK-8S was weaker or abolished compared to adults treated with saline during suckling. In adult rats given CCK-8S during suckling acute treatment with CCK-8S reduced food intake to the same extent as in the group treated with saline postnatally. 4. 4. These data show that early postnatal treatment with the CCK-A receptor antagonist L364.718 has an impact on the hypophagic response to CCK-8S in later life.