Current urologic care for testicular germ cell tumors in pediatric and adolescent patients

Abstract Testicular germ cell tumors make up 0.5% of pediatric malignancies, and 14% of adolescent malignancies. Young boys have primarily pure teratoma and pure yolk sac histologies; however, adolescent histology is mostly mixed nonseminomatous germ cell tumor. Surgical excision of the primary tumo...

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Published inUrologic oncology Vol. 34; no. 2; pp. 65 - 75
Main Authors Grantham, Erin C., M.D, Caldwell, Brian T., M.D, Cost, Nicholas G., M.D
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.02.2016
Subjects
Adolescent
Child
Child, Preschool
Germ cell tumor
Humans
Male
Neoplasms, Germ Cell and Embryonal - therapy
Oncology
Pediatric
Testicular cancer
Testicular Neoplasms - therapy
Urology
Germ cell tumor
Oncology
Testicular cancer
Pediatric
Adolescent
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Summary:Abstract Testicular germ cell tumors make up 0.5% of pediatric malignancies, and 14% of adolescent malignancies. Young boys have primarily pure teratoma and pure yolk sac histologies; however, adolescent histology is mostly mixed nonseminomatous germ cell tumor. Surgical excision of the primary tumor is the crux of treatment. Chemotherapy, retroperitoneal lymph node dissection, and targeted treatment of distant metastases make even widely disseminated disease treatable. Since the discovery of platinum-based chemotherapy, testicular germ cell tumors are a highly curable disease. However, adolescents remain the group with the highest mortality. Focus has expanded beyond survival to emphasize quality of life issues when optimizing treatment algorithms.
ISSN:1078-1439
1873-2496
DOI:10.1016/j.urolonc.2015.06.008