Adhesion molecules and rejection of renal allografts

• Published in: Kidney international Vol. 51; no. 5; pp. 1476 - 1480
• Main Authors: Solez, Kim, Racusen, Lorraine C., Abdulkareem, Fatima, Kemeny, Eva, von Willebrand, Eeva, Truong, Luan D.
• Format: Journal Article Conference Proceeding
• Language: English
• Published: New York, NY Elsevier Inc 01.05.1997; Nature Publishing
• Subjects: Animals; Antigen Presentation; Biological and medical sciences; Cell Adhesion Molecules - physiology; Graft Rejection; Humans; Kidney Transplantation - immunology; Medical sciences; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgery of the urinary system; T-Lymphocytes - immunology; Human; Immunohistochemistry; Pathogenesis; Acute; Cell adhesion molecule; Transplantation; Homotransplantation; Kidney; Rejection; Pathology; Chronic; Histopathology; Urinary system; Diagnosis
• ISSN: 0085-2538; 1523-1755
• DOI: 10.1038/ki.1997.202

Adhesion molecules and rejection of renal allografts. Despite an increasing amount of immunohistochemical and molecular biology data relating to the pathogenesis of kidney transplant rejection, the pathological diagnosis of this condition still rests on routine light microscopy. The detection of changes in expression and distribution of adhesion molecules in renal allograft biopsies may open a new era of increased accuracy of rejection diagnosis. Of the various adhesion molecule reactivities, peritubular capillary VCAM-1 staining appears to be the most specific rinding for chronic rejection. This same staining reaction is seen in acute rejection, but may have less specificity in that setting.