Conserved hierarchical gain of chromosome 4 is an independent prognostic factor in high hyperdiploid pediatric acute lymphoblastic leukemia

• Published in: Leukemia research Vol. 52; pp. 28 - 33
• Main Authors: Vojcek, Á, Pajor, G, Alpár, D, Mátics, R, Pótó, L, Szuhai, K, Pajor, L
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.01.2017
• Subjects: Child; Child, Preschool; Chromosome Aberrations; Chromosomes, Human, Pair 4 - genetics; Diploidy; Female; Follow-Up Studies; Hematology, Oncology and Palliative Medicine; Humans; Hyperdiploidy; iFISH; Infant; Lymphoblastic leukemia; Male; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - diagnosis; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - genetics; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - mortality; Prognosis; Survival Analysis; Trisomy; TT; hyperdiploid high; pre-B pediatric acute lymphoblastic leukemia; double trisomies; DI; HHD; single nucleotide polymorphism; high hyperdiploid; hyperdiploidy; HeH; probability of overall survival; HeL; DT; pEFS; SNP; conventional cytogenetic analysis; pOS; WBC; white blood cell count; hyperdiploid; iMN8; CCA; MN; modal chromosome number; lymphoblastic leukemia; probability of event free survival; iFISH; prognosis; B-pALL; hyperdiploid low; interphase fluorescence in situ hybridization; triple trisomies; HD; DNA index; modal number by iFISH on eight chromosomes; Prognosis; Hyperdiploidy; Lymphoblastic leukemia
• ISSN: 0145-2126; 1873-5835
• DOI: 10.1016/j.leukres.2016.11.007

Highlights • 8 chromosomes defined modal number by iFISH can prognostically stratify B-pALL. • Modal number of ≥ 55 relates significantly to better outcome of hyperdiploid B-pALL. • Hyperdiploid B-pALL with ≥ 55 chromosomes reveals less complex subclonal landscape. • Highly conserved chromosomal gain is a unique feature of high hyperdiploid B-pALL. • Conserved hierarchical gain of chromosome 4 is an independent prognostic factor.