Urinary Disease in 2 Dogon Populations with Different Exposure to Schistosoma haematobium Infection: Progression of Bladder and Kidney Diseases in Children and Adults

• Published in: The Journal of infectious diseases Vol. 192; no. 12; pp. 2152 - 2159
• Main Authors: Kouriba, Bouréma, Traoré, Hamar A., Dabo, Abdoulaye, Sangaré, Lansana, Guindo, Hamadoun, Keita, Abdoul Salam, Reimert, Claus M., van Dam, Govert J., Deelder, André M., Doumbo, Ogobara, Dessein, Alain J.
• Format: Journal Article
• Language: English
• Published: Chicago, IL The University of Chicago Press 15.12.2005; University of Chicago Press; Oxford University Press
• Subjects: Adolescent; Adult; Age Factors; Animals; Antigens; Antigens, Helminth - analysis; Biological and medical sciences; Child; Child, Preschool; Disease Progression; Diseases caused by trematodes; Eosinophil Cationic Protein - analysis; Female; Fundamental and applied biological sciences. Psychology; Genetic diseases; Helminthic diseases; Hematologic diseases; Humans; Infections; Infectious diseases; Kidney diseases; Kidney Diseases - epidemiology; Kidney Diseases - parasitology; Kidney Diseases - physiopathology; Kidneys; Male; Mali - epidemiology; Medical sciences; Microbiology; Parasite Egg Count; Parasites; Parasitic diseases; Prevalence; Schistosoma haematobium - physiology; Schistosomiases; Schistosomiasis haematobia - epidemiology; Schistosomiasis haematobia - physiopathology; Sex Factors; Statistics as Topic; Urinary bladder; Urinary bladder diseases; Urinary Bladder Diseases - epidemiology; Urinary Bladder Diseases - parasitology; Urinary Bladder Diseases - physiopathology; Urine; Urine - chemistry; Mali; Human; Disease development; Kidney disease; Urinary system disease; Schistosoma haematobium; Microbiology; Trematode disease; Plathelmintha; Parasitosis; Urinary tract disease; Helminthiasis; Trematoda; Infection; Schistosomiasis; Helmintha; Adult; Bladder disease; Invertebrata; Child; Cystitis
• ISSN: 0022-1899; 1537-6613
• DOI: 10.1086/498214

BackgroundSchistosoma haematobium infection causes severe urinary disease and considerable mortality. The factors that determine disease progression from mild to severe stages are not fully understood MethodsHere we describe a cross-sectional epidemiological study of kidney and bladder diseases in 2 Dogon populations with different exposure to S. haematobium infection ResultsEarly and high exposure resulted in more-severe disease, especially among young subjects, without clear evidence of a more-rapid development of immunity. Nevertheless, 50%–60% of subjects of all age classes in both villages showed no evidence of disease. Kidney and bladder disease peaked biphasically among young subjects and adults >25 years old. The first peak corresponded with infections of maximum intensity, whereas the second peak occurred among adults with infections of very low intensity. Kidney disease was correlated with circulating anodic antigen concentration in serum, whereas bladder disease was correlated with egg count and eosinophil cationic protein concentration in urine. Kidney and bladder disease did not correlate. Severe kidney disease was more frequent in certain families ConclusionsThe frequency of urinary disease is increased by infections acquired early during life, is regulated by strong clinical immunity in certain subjects, and may be dependent on hereditary factors. Kidney and bladder disease may involve different mechanisms of pathogenesis, which may differ between children and adults