Differential effect of tetradecythioacetic acid on the renin-angiotensin system and blood pressure in SHR and 2-kidney, 1-clip hypertension
The tetradecythioacetic acid (TTA) is a modified fatty acid known to exhibit pleiotropic effects. First, we compared the effect of TTA on the blood pressure in spontaneously hypertensive rats (SHR) with two-kidney, one-clip (2K1C)-hypertensive rats. Second, we examined mechanisms involved in the blo...
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Published in | American journal of physiology. Renal physiology Vol. 293; no. 3; pp. F839 - F845 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
United States
American Physiological Society
01.09.2007
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Subjects | |
Online Access | Get full text |
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Summary: | The tetradecythioacetic acid (TTA) is a modified fatty acid known to exhibit pleiotropic effects. First, we compared the effect of TTA on the blood pressure in spontaneously hypertensive rats (SHR) with two-kidney, one-clip (2K1C)-hypertensive rats. Second, we examined mechanisms involved in the blood pressure reduction. TTA had minor effect on systolic blood pressure (SBP) in young SHR up to 8 wk of age. In 2K1C we confirmed the blood pressure-lowering effect of TTA (SBP: 173 +/- 4 before vs. 138 +/- 3 mmHg after TTA, P < 0.001). No effect on SBP was seen in Wistar-Kyoto rat (WKY) controls. Plasma renin activity (PRA) was low in SHR and WKY controls and TTA did not change it. PRA decreased from 22.9 +/- 1.3 to 16.2 +/- 2.2 ng.ml(-1).h(-1) (P = 0.02) in 2K1C. Plasma ANG II concentration declined from 101 +/- 3 to 81 +/- 5 fmol/l after TTA treatment (P = 0.005). In the clipped kidney, tissue ANG I concentration decreased from 933 +/- 68 to 518 +/- 60 fmol/g tissue (P = 0.001), and ANG II decreased from 527 +/- 38 to 149 +/- 21 fmol/g tissue (P < 0.001) after TTA treatment. In the nonclipped kidney, TTA did not change ANG I and moderately reduced ANG II levels. The renal blood flow response to injection of ANG II into the nonclipped kidney was blunted compared with controls and normalized with TTA treatment (10 +/- 2 before vs. 20 +/- 2%, P < 0.001). The results indicate that TTA downregulates the renin-angiotensin system in high renin animals but has no effect in low renin models. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1931-857X 1522-1466 |
DOI: | 10.1152/ajprenal.00140.2007 |