Diffusion tensor imaging and magnetic resonance spectroscopy of the brain in a patient with Sturge-Weber syndrome

Quantitative brain MR spectroscopy (MRS) and diffusion tensor imaging (DTI) were used to characterize one patient with Sturge-Weber syndrome. Choline increases and N-acetylaspartate decreases were observed in pathologic frontal gray matter tissue compared to contralateral unaffected brain tissue wit...

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Published inActa radiologica (1987) Vol. 47; no. 9; p. 972
Main Authors Sijens, P E, Gieteling, E W, Meiners, L C, Sival, D A, Potze, J H, Irwan, R, Oudkerk, M
Format Journal Article
LanguageEnglish
Published England 01.11.2006
Subjects
Brain - pathology
Child
Diffusion Magnetic Resonance Imaging
Humans
Magnetic Resonance Spectroscopy
Male
Sturge-Weber Syndrome - pathology
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Summary:Quantitative brain MR spectroscopy (MRS) and diffusion tensor imaging (DTI) were used to characterize one patient with Sturge-Weber syndrome. Choline increases and N-acetylaspartate decreases were observed in pathologic frontal gray matter tissue compared to contralateral unaffected brain tissue without any change in the diffusion tensor imaging parameters (fractional anisotropy, apparent diffusion coefficient). The N-acetylaspartate decreases and/or choline increases observed here and in eight previously described Sturge-Weber patients probably reflect neuronal loss or dysfunction and demyelination as a result of recurrent seizures.
ISSN:0284-1851
DOI:10.1080/02841850600849100