Heritability, parental transmission and environment correlation of pediatric-onset type 2 diabetes mellitus and metabolic syndrome-related traits

Highlights • This evidence is the first to demonstrate the h2 of pediatric-onset type 2 DM. • The h2 of pediatric type 2 DM was 0.50 (p<1.0e-7), and were correlated through the mother. • High re and/or h2 was observed for most metabolic syndrome related traits. • This results highlight the comple...

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Published inDiabetes research and clinical practice Vol. 126; pp. 151 - 159
Main Authors Miranda-Lora, América L, Vilchis-Gil, Jenny, Molina-Díaz, Mario, Flores-Huerta, Samuel, Klünder-Klünder, Miguel
Format Journal Article
LanguageEnglish
Published Ireland Elsevier B.V 01.04.2017
Subjects
Adolescent
Adult
Anthropometry
Child
Children
Cross-Sectional Studies
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - ethnology
Diabetes Mellitus, Type 2 - etiology
Endocrinology & Metabolism
Environment
Female
Heritability and environment
Humans
Insulin - blood
Insulin Resistance
Life Style
Lipids - blood
Male
Metabolic syndrome
Metabolic Syndrome - blood
Metabolic Syndrome - ethnology
Metabolic Syndrome - etiology
Mexican Americans
Parents
Pedigree
Phenotype
Risk Factors
Type 2 diabetes mellitus
Heritability and environment
Type 2 diabetes mellitus
Children
Metabolic syndrome
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Summary:Highlights • This evidence is the first to demonstrate the h2 of pediatric-onset type 2 DM. • The h2 of pediatric type 2 DM was 0.50 (p<1.0e-7), and were correlated through the mother. • High re and/or h2 was observed for most metabolic syndrome related traits. • This results highlight the complex architecture of type 2 DM.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0168-8227
1872-8227
DOI:10.1016/j.diabres.2017.02.005