Immunogenicity of Pneumococcal Vaccine in Heart Transplant Recipients

• Published in: Clinical infectious diseases Vol. 32; no. 2; pp. 307 - 310
• Main Authors: Blumberg, Emily A., Brozena, Susan C., Stutman, Patricia, Wood, Diana, Phan, Hoang M., Musher, Daniel M.
• Format: Journal Article
• Language: English
• Published: Chicago, IL The University of Chicago Press 15.01.2001; University of Chicago Press
• Subjects: Adult; Age; Aged; Antibodies; Antibodies, Bacterial - blood; Antibody Formation; Antigens; Bacterial Capsules - immunology; Biological and medical sciences; Brief Report; Epidemiology. Vaccinations; Female; General aspects; Heart Transplantation; Humans; Immune response; Immunity, Active; Immunoglobulin G - blood; Infectious diseases; Male; Medical sciences; Middle Aged; Pneumococcal infections; Pneumococcal Infections - immunology; Pneumococcal Infections - prevention & control; Pneumococcal vaccine; Pneumococcal Vaccines - administration & dosage; Polysaccharides; Streptococcus pneumoniae - immunology; Transplantation; Vaccination; Heart; Immune response; Vaccination; IgG; Transplantation; Homotransplantation; Streptococcus pneumoniae; Infection; Prevention; Streptococcaceae; Immunoprophylaxis; Treatment; Immunogenicity; Surgery; Streptococcal infection; Bacteriosis; Bacteria; Micrococcales; Immunosuppressive agent
• ISSN: 1058-4838; 1537-6591
• DOI: 10.1086/318482

To assess the immunogenicity of pneumococcal vaccine in recipients of heart transplants, we immunized 35 long-term transplantation survivors with pneumococcal vaccine and measured the pre- and postvaccination IgG antibody titers to 5 representative vaccine capsular polysaccharides. Responses of heart transplant recipients to pneumococcal vaccine antigens were generally suppressed.