Two New Sesquiterpenes from Leaves of Nicotiana tabacum and their Antibacterial Activity

Two new sesquiterpenes, nicosesquites A and B ( 1 and 2 ) as well as four known sesquiterpenes ( 3–6 ) were isolated from the leaves of Nicotiana tabacum. Their structures were determined mainly by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds 1 and 2 were tested for...

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Published inChemistry of natural compounds Vol. 59; no. 3; pp. 497 - 501
Main Authors Cai, Jie-Yun, Dai, Jia-Meng, Xiong, Wen, Wang, Hui-Ping, Zhao, Wei, Qin, Shi-Chun, Li, Yong, Cai, Hao-Cheng, Hu, Qiu-Fen, Wang, Wei-Guang, Shang, Shan-Zhai
Format Journal Article
LanguageEnglish
Published New York Springer US 01.05.2023
Springer Nature
Springer
Springer Nature B.V
Subjects
Antibacterial agents
Chemistry
Chemistry and Materials Science
Chemistry, Medicinal
Chemistry, Organic
Chemistry/Food Science
Cigarettes
Life Sciences & Biomedicine
NMR
Nuclear magnetic resonance
Organic Chemistry
Pharmacology & Pharmacy
Physical Sciences
Plant Sciences
Science & Technology
Sesquiterpenes
Staphylococcus aureus
anti-MRSA activity
essence
sesquiterpenes
Nicotiana tabacum
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Summary:Two new sesquiterpenes, nicosesquites A and B ( 1 and 2 ) as well as four known sesquiterpenes ( 3–6 ) were isolated from the leaves of Nicotiana tabacum. Their structures were determined mainly by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds 1 and 2 were tested for their antimethicillin-resistant Staphylococcus aureus (anti-MRSA) activity. The results revealed that compounds 1 and 2 showed good inhibition with IZD of 13.4 ± 2.2, and 14.6 ± 2.4 mm, respectively. In addition, compounds 1 and 2 also have weak floral fragrances, and they have the potential value for use as an essence for cigarettes.
ISSN:0009-3130
1573-8388
DOI:10.1007/s10600-023-04034-3