Adenovirus-Associated Defective Virus Particles

Small, DNA-containing particles were separated from preparations of a simian adenovirus. These particles differed antigenically from the adenovirus. Replication of the particles in cell cultures was obtained only when they were inoculated simultaneously with adenoviruses. This suggests that these ad...

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Bibliographic Details
Published inScience (American Association for the Advancement of Science) Vol. 149; no. 3685; pp. 754 - 756
Main Authors Atchison, Robert W., Casto, Bruce C., William Mc D. Hammon
Format Journal Article
LanguageEnglish
Published United States American Association for the Advancement of Science 13.08.1965
Subjects
Adenoviridae
Adenoviruses
Animals
Antigens
Blood plasma
Chemical suspensions
Defective Viruses
DNA
DNA, Viral
Dosage
Electron microscopy
Electrons
Enzymes
Haplorhini
Immunologic Tests
Kidneys
Mice
Microscopy
Microscopy, Electron
Old Medline
Satellite Viruses
Tissue Culture Techniques
Virion
Virology
Virus Cultivation
Viruses
VIRUS CULTIVATION
EXPERIMENTAL LAB STUDY
ANTIGENS
MICROSCOPY, ELECTRON
DNA, VIRAL
MONKEYS
TISSUE CULTURE
ADENOVIRUS
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Summary:Small, DNA-containing particles were separated from preparations of a simian adenovirus. These particles differed antigenically from the adenovirus. Replication of the particles in cell cultures was obtained only when they were inoculated simultaneously with adenoviruses. This suggests that these adenovirus-associated particles behave as defective viruses.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0036-8075
1095-9203
DOI:10.1126/science.149.3685.754